PMID: 9182241Feb 1, 1996Paper

Kinetic analysis of taurine influx into cerebral cortical slices from adult and developing mice in different incubation conditions

Neurochemical Research
S S Oja, P Saransaari

Abstract

The influx of taurine into cerebral cortical slices was studied with 3-day-old and 3-month-old mice in different ionic environments in incubation medium. In standard Krebs-Ringer medium the influx comprised two saturable uptake components, high- and low-affinity, and non-saturable penetration. In isoosmotic medium potassium stimulation abolished the high-affinity uptake in both age groups. In hyperosmotic medium the high-affinity uptake disappeared totally in 3-day-old mice and partially in 3-month-old mice. The high-affinity uptake was also obliterated in hypoosmotic medium and in the absence of chloride ions in both age groups. The low-affinity uptake was abolished by potassium stimulation in 3-month-olds and strongly inhibited in 3-day-olds. Hypoosmotic and chloride-free media also inhibited the low-affinity uptake at both ages. Non-saturable influx was greatly diminished in chloride-free media. The taurine uptake systems are thus strongly inhibited in incubation conditions which simultaneously evoke apparent release of taurine from cerebral cortical slices. This inhibition contributes to the magnitude of the estimated release, which in vitro represents overflow of released taurine molecules which escape recapture by the mem...Continue Reading

References

Jan 1, 1978·Neuroscience·P Kontro, S S Oja
Aug 1, 1976·Acta Physiologica Scandinavica·M L Laakso, S S Oja
Oct 1, 1976·Neuropharmacology·A Nistri, A Constanti
Jan 1, 1992·Canadian Journal of Physiology and Pharmacology·A Schousboe, H Pasantes-Morales
Jan 1, 1992·Advances in Experimental Medicine and Biology·S S Oja, P Saransaari
Jan 1, 1992·Progress in Neurobiology·P Saransaari, S S Oja
May 1, 1992·Journal of Neuroscience Research·R Sánchez-OleaH Pasantes-Morales
Sep 1, 1990·Journal of Neuroscience Research·A SchousboeH Pasantes-Morales
May 1, 1990·Neurochemical Research·R Sánchez Olea, H Pasantes-Morales
Feb 1, 1989·Journal of Neuroscience Research·R A PhilibertG R Dutton
Jan 1, 1989·Progress in Neurobiology·R J Huxtable
Jan 1, 1987·Journal of Neuroscience Research·S S Oja, P Kontro
Dec 6, 1974·Brain Research·R W CutlerD S Dudzinski
Nov 1, 1974·Journal of Neurochemistry·R W Cutler, D S Dudzinski
May 1, 1973·Journal of Neurochemistry·P Lähdesmäki, S S Oja
Dec 1, 1980·Journal of Neurochemistry·S S Oja, P Kontro
Apr 1, 1994·Neurochemical Research·J MoránH Pasantes-Morales
Dec 1, 1993·The American Journal of Physiology·P S Jackson, K Strange
Jan 1, 1983·Neurochemistry International·I B LindénS S Oja

❮ Previous
Next ❯

Citations

Jun 1, 1996·Metabolic Brain Disease·S S Oja, P Saransaari
Oct 3, 1998·Brain Research·P Saransaari, S S Oja
Jun 17, 2000·Progress in Neurobiology·S S Oja, P Saransaari
Oct 31, 2002·The European Journal of Neuroscience·A N ChepkovaO A Sergeeva
Apr 26, 2011·Neuroscience Letters·Mohammadreza Ghandforoush-SattariHormoz Ayromlou
Dec 22, 2004·The Journal of Biological Chemistry·Marie Thérèse BessonSerge Birman
Apr 14, 2004·The European Journal of Neuroscience·Nuria del OlmoJosé M Solís

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.