Kinetic analysis of the growth rate of sporadic and hereditary medullary thyroid carcinoma: comparing the postoperative calcitonin-doubling rate with the hypothetical preoperative tumor volume-doubling rate

Thyroid Research
Minoru KiharaAkihiro Miya

Abstract

Our previous kinetic analyses of changes in the tumor volume (TV) of papillary thyroid microcarcinomas during active surveillance revealed that the tumors' growth varied over time from rather rapid growth to shrinkage and that the hypothetical TV-doubling rates (DRs) before the patients' presentation were much larger than their observed TV-DRs, indicating that rapid growth phases preceded their presentation. Whether this phenomenon also occurs in medullary thyroid carcinoma (MTC) was unknown. We retrospectively analyzed the cases of 46 MTC patients (18 hereditary, 28 sporadic; 9-80 years old at surgery, median 53.5 years; 19 males and 27 females) with elevated postoperative calcitonin (Ct) measured with the electrochemiluminescence immunoassay suggesting persistent disease. We calculated each patient's Ct-DR and his/her hypothetical TV-DR, using the tumor size and age at surgery. Ct-DRs (/year) after surgery were > 0.5, 0.1-0.5, - 0.1-0.1, and < - 0.1 in 9, 21, 12, and 4 patients, respectively (median 0.17). The hypothetical TV-DRs (/year) before surgery were > 1, 0.5-1.0, 0.1-0.5 and < 0.1 in 11, 21, 14, and 0 patients, respectively (median 0.60). The hypothetical TV-DR was higher than the observed Ct-DR in 41 of the 46 MTC pa...Continue Reading

References

Aug 11, 2005·The Journal of Clinical Endocrinology and Metabolism·Jacques BarbetUNKNOWN GTE Study Group
Apr 12, 2007·World Journal of Surgery·Jeffrey F Moley, Elizabeth A Fialkowski
Sep 5, 2013·Thyroid : Official Journal of the American Thyroid Association·Yasuhiro ItoAkihiro Miya
Mar 27, 2015·Thyroid : Official Journal of the American Thyroid Association·Samuel A WellsUNKNOWN American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma
Oct 28, 2019·Thyroid : Official Journal of the American Thyroid Association·Yasuhiro ItoAkihiro Miya

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