PMID: 18424609Apr 22, 2008Paper

Kinetic analysis shows that vitamin A disposal rate in humans is positively correlated with vitamin A stores

The Journal of Nutrition
Christopher J CifelliMichael H Green

Abstract

Vitamin A (VA) kinetics, storage, and disposal rate were determined in well-nourished Chinese and U.S. adults using model-based compartmental analysis. [(2)H(8)]Retinyl acetate (8.9 micromol) was orally administered to U.S. (n = 12; 59 +/- 9 y; mean +/- SD) and Chinese adults (n = 14; 54 +/- 4 y) and serum tracer and VA concentrations were measured from 3 h to 56 d. Using the Windows version of the Simulation, Analysis and Modeling software, we determined that the average time from dosing until appearance of labeled retinol in serum was greater in U.S. subjects (40.6 +/- 8.47 h) than in Chinese subjects (32.2 +/- 5.84 h; P < 0.01). Model-predicted total traced mass (898 +/- 637 vs. 237 +/- 109 micromol), disposal rate (14.7 +/- 5.87 vs. 5.58 +/- 2.04 micromol/d), and system residence time (58.9 +/- 28.7 vs. 42.9 +/- 14.6 d) were greater in U.S. than in Chinese subjects (P < 0.05). The model-predicted VA mass and VA mass estimated by deuterated retinol dilution at 3 and 24 d did not differ. VA disposal rate was positively correlated with VA traced mass in Chinese (R(2) = 0.556), U.S. (R(2) = 0.579), and all subjects (R(2) = 0.808). Additionally, VA disposal rate was significantly correlated with serum retinol pool size (R(2) = 0...Continue Reading

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Citations

Jun 19, 2010·Experimental Biology and Medicine·Sara A ArscottSherry A Tanumihardjo
Oct 2, 2020·Current Developments in Nutrition·Bryan M GannonSaurabh Mehta
Oct 30, 2012·The Journal of Biological Chemistry·Philomena AlapattTimothy E Graham
Mar 7, 2020·The Journal of Nutrition·Veronica Lopez-TerosHumberto Astiazaran-Garcia
Apr 25, 2020·Experimental Biology and Medicine·Jesse SheftelSherry A Tanumihardjo
Aug 20, 2009·Critical Reviews in Food Science and Nutrition·A Catharine RossElizabeth Julien
Jun 19, 2009·The Journal of Nutrition·Charlene C HoAndrew J Clifford

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