Kinetic and mechanistic requirements for helping CD8 T cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
Paola AgnelliniAnnette Oxenius

Abstract

The requirements for the generation of fully competent long-lived memory CD8 T cells and in particular the role and the mechanisms of help from CD4 T cells remain ill-defined. Memory CD8 T cells generated in the absence of CD4 T cell help often have an impaired recall proliferation and are thus unable to confer protection against certain pathogens. However, the timing and the mechanisms involved in the delivery of help are still unclear and differ between various experimental systems. In this study, we investigated the role of CD4 T help in generating memory CD8 T cells in a defined heterologous prime-boost system, consisting of priming with replication incompetent virus-like particles and challenge with recombinant vaccinia virus, both sharing only a common lymphocytic choriomeningitis virus-derived CD8 T cell epitope. We show in this system that delivery of help is only essential during the challenge phase for recall proliferation of memory CD8 T cells. Furthermore, we show that generation of proliferation-competent memory CD8 T cells is independent of CD40 and CCR5 and that in vivo IL-2 supplementation neither during priming nor during challenge was able to rescue recall proliferation of "unhelped" memory CD8 T cells.

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Citations

Apr 30, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Melanie WieselAnnette Oxenius
Dec 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melanie WieselAnnette Oxenius
Apr 28, 2012·European Journal of Immunology·Melanie Wiesel, Annette Oxenius
Oct 11, 2013·European Journal of Immunology·Gregor BedenikovicAnnette Oxenius
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Oct 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melanie WieselAnnette Oxenius
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