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Kinetic and spectral studies of type I and type II compounds with rat hepatic microsomes in the presence of the major metabolite of diphenylhydantoin

Drug Metabolism and Disposition : the Biological Fate of Chemicals

Jan 1, 1975

Salomon A StavchanskyW C Lubawy

PMID: 1233

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Abstract

The nature of the inhibitory effects of the major metabolite of diphenylhydantoin, 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH), on the in vitro metabolism of ethylmorphine and aniline by rat hepatic microsomes was examined. The N-demethylation of ethylmorphine was competitively inhibit...read more

Mentioned in this Paper

Fractures, Open
Evipan
Aniline
Morphinans
Metabolic Inhibition
Depression, Chemical
Metabolic Aspects
Phenytoin
5-phenylhydantoin
Metabolite
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  • Kinetic and spectral studies of type I and type II compounds with rat hepatic microsomes in the presence of the major metabolite of diphenylhydantoin

    Drug Metabolism and Disposition : the Biological Fate of Chemicals

    Jan 1, 1975

    Salomon A StavchanskyW C Lubawy

    PMID: 1233

    DOI:

    Abstract

    The nature of the inhibitory effects of the major metabolite of diphenylhydantoin, 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH), on the in vitro metabolism of ethylmorphine and aniline by rat hepatic microsomes was examined. The N-demethylation of ethylmorphine was competitively inhibit...read more

    Mentioned in this Paper

    Fractures, Open
    Evipan
    Aniline
    Morphinans
    Metabolic Inhibition

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