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Kinetic consequences of the inhibition by ATP of the metabolism of inositol (1,4,5) trisphosphate and inositol (1,3,4,5) tetrakisphosphate in liver. Different effects upon the 3- and 5-phosphatases

Cellular Signalling

Jan 1, 1990

S B Shears

PMID: 2169288

Abstract

A kinetic analysis was undertaken of the inhibition by 5 mM MgATP of Ins(1,4,5)P3 5-phosphatase in 100,000 g particulate fractions prepared from liver homogenates. The Km for Ins(1,4,5)P3 was increased by 44% (from 16 to 23 microM). The competitive nature of the inhibition was confirmed...read more

Mentioned in this Paper

Metabolic Process, Cellular
Inositol Phosphates
1,4,5-Triphosphate-1,2,4,5-Tetrakisphosphate 5-Phosphatase
Phosphoric Monoester Hydrolases
August Rats
Adenosine Triphosphate, Magnesium Salt
Metabolic Pathway
inositol-1,3,4,5-tetrakisphosphate
Phosphoric Monoester Hydrolase Activity
High Pressure Liquid Chromatography Procedure
Paper Details
References
  • References8
  • Citations3
1

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Kinetic consequences of the inhibition by ATP of the metabolism of inositol (1,4,5) trisphosphate and inositol (1,3,4,5) tetrakisphosphate in liver. Different effects upon the 3- and 5-phosphatases

Cellular Signalling

Jan 1, 1990

S B Shears

PMID: 2169288

DOI:

Abstract

A kinetic analysis was undertaken of the inhibition by 5 mM MgATP of Ins(1,4,5)P3 5-phosphatase in 100,000 g particulate fractions prepared from liver homogenates. The Km for Ins(1,4,5)P3 was increased by 44% (from 16 to 23 microM). The competitive nature of the inhibition was confirmed...read more

Mentioned in this Paper

Metabolic Process, Cellular
Inositol Phosphates
1,4,5-Triphosphate-1,2,4,5-Tetrakisphosphate 5-Phosphatase
Phosphoric Monoester Hydrolases
August Rats
Adenosine Triphosphate, Magnesium Salt
Metabolic Pathway
inositol-1,3,4,5-tetrakisphosphate
Phosphoric Monoester Hydrolase Activity
High Pressure Liquid Chromatography Procedure

Similar Papers Found In These Feeds

GPCRs Signaling Pathway

G-protein coupled receptors (GPCRs) are membrane receptors implicated in the pathophysiology of various diseases, including neurodegenerative disorders, infectious diseases, and cancer. Here is the latest research on GPCR signaling pathway.

Related Papers

Paper Details
References
  • References8
  • Citations3
1
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