PMID: 6978152Mar 29, 1982Paper

Kinetic considerations for the regulation of adenosine and deoxyadenosine metabolism in mouse and human tissues based on a thymocyte model

Biochimica Et Biophysica Acta
F F Snyder, T Lukey

Abstract

Metabolic regulation at a branch point may be determined primarily by relative enzyme activities and affinity for common substrate. Adenosine and deoxyadenosine are both phosphorylated and deaminated and their metabolism was studied in intact mouse thymocytes. From kinetic considerations of two activities competing for a common substrate, the deamination:phosphorylation ratio, vd/vk, at high nucleoside concentration, [S] congruent to infinity, is equal to Vd/Vk, or 34 and 1090 for adenosine and deoxyadenosine, respectively. At low substrate concentrations, [S] congruent to o, vd/vk is equal to VdKkm/VkKdm, or 0.7 and 285 for adenosine and deoxyadenosine, respectively. The analysis was extended to other mouse and human tissues by measurement of adenosine kinase, deoxyadenosine kinase and adenosine deaminase activities. All tissues were found to preferentially deaminate deoxyadenosine. Three tissue types were apparent with respect to adenosine metabolism: those which preferentially phosphorylate adenosine at all concentrations, those which switch from phosphorylation to deamination between low and high adenosine concentration and those for which deamination is quantatively important at all concentrations. Lymphoid tissues are rep...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D A CarsonJ E Seegmiller
May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R L WortmannI H Fox
May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D A CarsonL Thompson
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·N L EdwardsI H Fox
Sep 1, 1976·The Journal of Clinical Investigation·F F SnyderJ E Seegmiller
Jul 1, 1972·The American Journal of Physiology·J SchraderR Rubio
Jun 30, 1971·Biochimica Et Biophysica Acta·F L Meyskens, H E Williams
Jan 1, 1980·Pharmacology & Therapeutics·J F HendersonJ K Lowe
Jan 1, 1965·Comparative Biochemistry and Physiology·T G BRADY, C I O'DONOVAN

❮ Previous
Next ❯

Citations

Jan 1, 1983·The International Journal of Biochemistry·G J Peters, J H Veerkamp
Mar 1, 1995·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A MinelliI Mezzasoma
Sep 29, 2000·Pharmacology & Therapeutics·J Spychala
May 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Detlev BoisonHanns Mohler
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·J SpychalaB S Mitchell
Jul 29, 2009·Biochemical and Biophysical Research Communications·Xianying Amy CuiRadhey S Gupta
Aug 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A HolstegeJ Hoppmann
Jul 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H G LeserW Gerok
Aug 1, 1997·Circulation Research·U K DeckingJ Schrader
Jan 1, 1986·CRC Critical Reviews in Biochemistry·A G Hinnebusch
Aug 18, 2006·Molekuliarnaia biologiia·G A ZhuravlevaS G Inge-Vechtomov
Aug 3, 2019·International Journal of Molecular Sciences·Kai SongYejing Wang
May 3, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Preetiner Pal SinghAparajita Khatri
Jan 1, 1985·The American Journal of Physiology·M J HollandJ K Kelleher
Sep 14, 2002·The Journal of Laboratory and Clinical Medicine·Jozef Spychala, Beverly S Mitchell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.