Kinetic control of translation initiation in bacteria

Critical Reviews in Biochemistry and Molecular Biology
Pohl Milón, Marina V Rodnina


Translation initiation is a crucial step of protein synthesis which largely defines how the composition of the cellular transcriptome is converted to the proteome and controls the response and adaptation to environmental stimuli. The efficiency of translation of individual mRNAs, and hence the basal shape of the proteome, is defined by the structures of the mRNA translation initiation regions. Initiation efficiency can be regulated by small molecules, proteins, or antisense RNAs, underscoring its importance in translational control. Although initiation has been studied in bacteria for decades, many aspects remain poorly understood. Recent evidence has suggested an unexpected diversity of pathways by which mRNAs can be recruited to the bacterial ribosome, the importance of structural dynamics of initiation intermediates, and the complexity of checkpoints for mRNA selection. In this review, we discuss how the ribosome shapes the landscape of translation initiation by non-linear kinetic processing of the transcriptome information. We summarize the major pathways by which mRNAs enter the ribosome depending on the structure of their 5' untranslated regions, the assembly and the structure of initiation intermediates, the individual a...Continue Reading


Jul 1, 1990·Molecular Microbiology·N Jacques, Marc Dreyfus
Jan 11, 1991·Nucleic Acids Research·Irina V BoniN V Tzareva
Jun 26, 1990·Biochemistry·Claudio O Gualerzi, C L Pon
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·W F JacobA E Dahlberg
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A Hui, H A de Boer
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W E TapprichA E Dahlberg
Dec 1, 1989·Genes & Development·D HartzL Gold
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R A CalogeroClaudio O Gualerzi
Jan 1, 1988·Annual Review of Biochemistry·L Gold
Jan 1, 1982·Molecular & General Genetics : MGG·M Kitakawa, K Isono
Jan 7, 1994·Journal of Molecular Biology·M H de Smit, J van Duin
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Anna La TeanaClaudio O Gualerzi
Jul 1, 1996·Molecular Microbiology·Jacqueline K SussmanRobert W Simons
Dec 23, 1998·Biochemistry and Molecular Biology International·Kim Kusk MortensenHans Uffe Sperling-Petersen
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·J P McCutcheonJ Frank
May 3, 2000·The EMBO Journal·Jerneja TomsicClaudio O Gualerzi
Jul 6, 2000·Extremophiles : Life Under Extreme Conditions·N TolstrupI G Clausen
Oct 3, 2000·The EMBO Journal·M GuenneuguesClaudio O Gualerzi
Nov 10, 2000·Nucleic Acids Research·J WeinerG F Browning
Aug 14, 2001·The EMBO Journal·D PetrelliClaudio O Gualerzi
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·J SenguptaJ Frank
Oct 31, 2001·Molecular Cell·A Dallas, Harry F Noller
Jun 22, 2002·FEMS Microbiology Letters·Sonja GrillUdo Bläsi
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jonathan A BernsteinStanley N Cohen
Oct 9, 2002·Current Protein & Peptide Science·Rolf Boelens, Claudio O Gualerzi
Feb 26, 2003·The Journal of Biological Chemistry·Brian Søgaard LaursenDavid W Hoffman
May 24, 2003·Cold Spring Harbor Symposia on Quantitative Biology·Claudio O GualerziC L Pon
May 4, 2004·Biochemical and Biophysical Research Communications·Dieter VogesBernd Buchberger
Feb 17, 2005·Journal of Molecular Biology·Scott P HennellyWalter E Hill
Mar 10, 2005·Microbiology and Molecular Biology Reviews : MMBR·Brian Søgaard LaursenHans Uffe Sperling-Petersen
May 17, 2005·Molecular Cell·Frank PeskeWolfgang Wintermeyer
Aug 6, 2005·Protein Science : a Publication of the Protein Society·Hans WienkRolf Boelens
Nov 8, 2005·Science·Barbara S SchuwirthJamie H Doudna Cate
Nov 15, 2005·Nature Structural & Molecular Biology·Alexander G MyasnikovBruno P Klaholz
Nov 26, 2005·Molecular Cell·Laura Lancaster, Harry F Noller
Dec 20, 2005·The EMBO Journal·Ivan B LomakinTatyana V Pestova
Jan 28, 2006·Biochemical and Biophysical Research Communications·Tokumasa Nakamoto
Apr 1, 2006·Molecular Microbiology·Haining JinLeif A Isaksson
Apr 8, 2006·Molecular Cell·Sean M Studer, Simpson Joseph
May 26, 2006·The EMBO Journal·Ayman AntounMåns Ehrenberg
Aug 23, 2006·Journal of Bacteriology·Patricia SkorskiSylvie Hermann-Le Denmat
Aug 29, 2006·Journal of Molecular Biology·Enrico CasertaClaudio O Gualerzi
Sep 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Pohl MilónClaudio O Gualerzi
Oct 20, 2006·Nature·G YusupovaM Yusupov
Jan 24, 2007·Molecular Microbiology·Gregory S Allen, Joachim Frank
Jan 25, 2007·Molecular Cell·Attilio FabbrettiClaudio O Gualerzi
Sep 18, 2007·Journal of Molecular Biology·Christina GrigoriadouBarry S Cooperman
Nov 2, 2007·BMC Molecular Biology·Vladimir VimbergTanel Tenson
Jun 24, 2008·Molecular Cell·Pohl MilónMarina V Rodnina
Jul 16, 2008·Journal of Molecular Biology·Namiko MitaraiSteen Pedersen
Sep 2, 2008·Nature·Angelita SimonettiBruno P Klaholz
Nov 18, 2008·Cellular and Molecular Life Sciences : CMLS·Angelita SimonettiM Yusupov
Mar 24, 2009·Journal of Bacteriology·Karla D PassalacquaNicholas H Bergman
Apr 11, 2009·Science·Grzegorz KudlaJoshua B Plotkin
Jun 6, 2009·Current Opinion in Structural Biology·Alexander G MyasnikovBruno P Klaholz
Jul 15, 2009·Molecular Cell·R Andrew MarshallJoseph D Puglisi
Nov 4, 2009·RNA Biology·Thomas GeissmannPascale Romby
Feb 6, 2010·Molecular Microbiology·Anna ZorzetDan I Andersson
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tamir TullerEytan Ruppin
Apr 14, 2010·Journal of Molecular Biology·Chenhui HuangSuparna Sanyal
Aug 24, 2010·Journal of Molecular Biology·Malin AllertHomme W Hellinga
Jul 28, 2011·The FEBS Journal·Jaroslav M BelotserkovskyLeif A Isaksson
Oct 13, 2011·Biochemistry·Louise Carøe Vohlander RasmussenKim Kusk Mortensen
Nov 24, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Joshua P FerreiraClifford L Wang
Nov 29, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Jessie E P SunRustem I Litvinov
Dec 15, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·V Mohana RaoM P J S Anandraj
Feb 7, 2012·The Journal of Biological Chemistry·Hans WienkRolf Boelens


May 4, 2013·Chemical Reviews·Sushil Kumar Tomar, Irina Artsimovitch
Sep 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andrian GutuDavid M Kehoe
Jun 1, 2012·Nucleic Acids Research·Dmitry E BurakovskyOlga A Dontsova
Sep 26, 2013·PloS One·D V IgnatovT L Azhikina
Aug 1, 2014·PLoS Genetics·Jared M SchraderLucy Shapiro
Mar 15, 2013·FEBS Letters·Aleksandra Filipovska, Oliver Rackham
May 6, 2015·International Journal of Molecular Sciences·Xabier Agirrezabala, Mikel Valle
Feb 19, 2016·Proceedings of the National Academy of Sciences of the United States of America·Hiroshi YamamotoKnud H Nierhaus
Sep 5, 2015·Nucleic Acids Research·Akanksha GoyalMarina V Rodnina
Jul 31, 2013·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Shirley S Daube, Roy H Bar-Ziv
Aug 12, 2015·Cellular and Molecular Life Sciences : CMLS·Claudio O Gualerzi, Cynthia L Pon
Jul 16, 2013·Current Opinion in Structural Biology·Huan-Xiang Zhou, Paul A Bates
Apr 30, 2015·Biochimie·Adélaïde Saint-Léger, Lluís Ribas de Pouplana
Nov 8, 2012·RNA Biology·Stefan H KnauerIrina Artsimovitch
Sep 24, 2016·Quarterly Reviews of Biophysics·Jin ChenJoseph D Puglisi
Jul 2, 2016·Protein Science : a Publication of the Protein Society·Ramachandra DongreHans Wienk
May 21, 2016·Protein Science : a Publication of the Protein Society·Marina V Rodnina
Nov 29, 2016·Scientific Reports·Kseniya A AkulichSergey E Dmitriev
Apr 18, 2018·Cold Spring Harbor Perspectives in Biology·Marina V Rodnina
Apr 4, 2013·Nature Reviews. Microbiology·Andrew Robinson, Antoine M van Oijen
Apr 9, 2020·World Journal of Microbiology & Biotechnology·Tianwen WangLei Nie
Jul 6, 2013·Biopolymers·Lili K Doerfel, Marina V Rodnina
Jul 20, 2019·Proceedings of the National Academy of Sciences of the United States of America·Cédric RomillyE Gerhart H Wagner
May 9, 2020·Communications Biology·Patrick J ShillingDaniel O Daley
Nov 15, 2012·Scientific Reports·Vladimir A MitkevichVasili Hauryliuk
Jan 11, 2019·International Journal of Molecular Sciences·Jing ZhaoGong Zhang
Oct 28, 2018·Nature Communications·Mahmoud M Al-BassamKarsten Zengler
Oct 18, 2020·Nature Communications·Xiao-Pan HuMartin J Lercher
Nov 18, 2020·The Journal of Biological Chemistry·Sunil Shetty, Umesh Varshney

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