PMID: 8587156Oct 1, 1995Paper

Kinetic disposition of triclabendazole in buffalo compared to cattle

Journal of Veterinary Pharmacology and Therapeutics
P K Sanyal

Abstract

Concentrations of triclabendazole sulfoxide and its sulfone metabolite in plasma were measured in buffalo and cross-bred cattle after single intraruminal administration of triclabendazole at two different doses. Plasma concentrations of both metabolites were significantly lower in buffalo than cattle at both doses, which resulted in a smaller area under the concentration-time curve, a lower concentration maximum and a lower relative bioavailability. Thus, the recommended doses of 12 mg/kg body weight for the treatment of bubaline fascioliasis may not be valid for buffalo because of the substantially lower uptake of the drug in this species.

References

Jun 1, 1990·Australian Veterinary Journal·S E EstuningsihM R Knox
Sep 1, 1988·Journal of Veterinary Pharmacology and Therapeutics·L D Kinabo, J A Bogan
Mar 1, 1987·Journal of Veterinary Pharmacology and Therapeutics·D R HennessyR K Prichard
Dec 1, 1986·Journal of Veterinary Pharmacology and Therapeutics·N A Mohammed AliR J Richards
Sep 1, 1985·Journal of Veterinary Pharmacology and Therapeutics·D R HennessyJ W Steel
Sep 1, 1983·Veterinary Parasitology·K WolffH Lutz
Jan 14, 1984·The Veterinary Record·K TurnerR J Richards
Feb 1, 1994·Journal of Veterinary Pharmacology and Therapeutics·P K Sanyal

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Citations

Feb 22, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·F ImperialeC Lanusse
Jun 1, 1997·Journal of Veterinary Pharmacology and Therapeutics·P K Sanyal
Nov 28, 2008·Veterinary Parasitology·Hatem A ShalabyReem O A Kamel
Nov 23, 2006·Veterinary Parasitology·Ahmed G HegaziHatem A Shalaby
May 28, 2014·New Zealand Veterinary Journal·P OrtizL Alvarez

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