May 1, 1976

Kinetic effect of some aliphatic amines on yeast alcohol dehydrogenase

Canadian Journal of Biochemistry
M J Dove, C S Tsai

Abstract

Initial rate studies of ethanol oxidation catalyzed by yeast alcohol dehydrogenase (EC 1.1.1.1) were carried out in the presence of varying concentrations of aliphatic amines over the pH range from 8.0 to 10.5. Aliphatic amines either activate or inhibit the enzyme depending on whether the pH is greater or less than 9.5 suggesting that the protonated amines activate and the nonprotonated amines inhibit the enzyme. Aliphatic amines activate yeast alcohol dehydrogenase by decreasing Kb while they inhibit the enzyme by increasing both Ka and Kia. When both protonated and nonprotonated amines are present in solution, either overall activation or inhibition will be observed depending on the relative concentration of the two amine species.

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Mentioned in this Paper

Ethanol
Amines
Alcohol Oxidoreductases
NADH
Saccharomyces cerevisiae
Hydrogen-Ion Concentration
Computers, Digital
Mathematics

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