PMID: 9185970Jun 1, 1997Paper

Kinetic gait analysis assessment of meloxicam efficacy in a sodium urate-induced synovitis model in dogs

American Journal of Veterinary Research
Alan R CrossT J Keefe

Abstract

To examine the ability of meloxicam, a cyclooxygenase inhibitor, to mediate the effects of sodium urate-induced acute stifle synovitis in dogs. 12 clinically normal adult hound-type dogs. A blinded, randomized, controlled single crossover design study was performed to determine the efficacy of meloxicam, using 2 dosage groups. In 2 experimental phases, dogs, according to group, received meloxicam (0.1 or 0.5 mg/kg of body weight) or matched volume of meloxicam vehicle, with a washout period of 21 to 28 days between phases. Blood samples for hematologic and biochemical analysis, as well as synovial fluid or cytologic analysis, were collected immediately before and approximately 24 hours after articular challenge of dogs under propofol anesthesia. Ground reaction forces (GRF) and subjective clinical scores were determined before and at 4, 8, 12, and 24 hours after articular challenge. Vertical force data included peak force, impulse, limb loading, and unloading rates. Craniocaudal data were divided into braking and propulsion phases and consisted of peak force and associated impulses. Except for propulsion impulse at 24 hours, all GRF variables were significantly greater at all post-synovitis induction times in the group receivin...Continue Reading

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