PMID: 3758062Sep 1, 1986Paper

Kinetic implications of the occurrence of several relaxations in the conformational transition of mnemonical enzymes

European Journal of Biochemistry
J RicardM Bidaud

Abstract

If the conformational transition involved in enzyme memory occurs in several elementary steps, the time constant of the overall 'slow' relaxation is mostly determined by the individual values of the rate constants pertaining to the overall transconformation. The extent of kinetic co-operativity of the enzyme reaction, however, is mostly controlled by the degree of reversibility of the elementary steps of the conformational transition. There is then no simple relation between the time scale of the 'slow' transition and the extent of kinetic co-operativity of the enzyme reaction. A slow transition of about 10(-3) s-1 is therefore perfectly compatible with a strong positive or negative co-operativity and in particular with the negative co-operativity observed with wheat germ hexokinase LI. The relationship that has been established recently [Pettersson, G. (1986) Eur. J. Biochem. 154, 167-170] between the 'slow' enzyme relaxation and the extent of kinetic co-operativity holds only in the specific case where the transconformation occurs in one step. Owing to the possible occurrence of a multistep conformation change, the lack of this relationship means nothing as to the validity, or the invalidity, of the concept of mnemonical tran...Continue Reading

References

Mar 15, 1978·European Journal of Biochemistry·M O Monneuse-DoubletJ Buc
Jan 1, 1979·Methods in Enzymology·H J Fromm
Jul 1, 1977·The Biochemical Journal·A C Storer, A Cornish-Bowden
Nov 1, 1977·European Journal of Biochemistry·J RicardJ C Meunier
Jan 2, 1986·European Journal of Biochemistry·G Pettersson
Nov 1, 1974·European Journal of Biochemistry·J RicardJ Buc
Nov 1, 1974·European Journal of Biochemistry·J C MeunierJ Ricard
Oct 15, 1980·Archives of Biochemistry and Biophysics·M Katz, J Westley
Jan 1, 1983·Annual Review of Biochemistry·M Karplus, J A McCammon
Feb 1, 1984·Biochimie·C PapanicolaouJ Ninio
Jan 1, 1980·Methods in Enzymology·K E Neet, G R Ainslie

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Citations

Jul 15, 1987·European Journal of Biochemistry·J Ricard, A Cornish-Bowden
Dec 20, 1988·Biochimica Et Biophysica Acta·P J Lecomte, J Ninio
Jan 7, 1987·Journal of Theoretical Biology·A Cornish-Bowden, M L Cárdenas

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