PMID: 8946855Dec 1, 1996Paper

Kinetic intermediates in the formation of the cytochrome c molten globule

Nature Structural Biology
W Colón, H Roder

Abstract

The relationship between molten globules and transient intermediates in protein folding has been explored by equilibrium and kinetic analysis of the compact acid-denatured A-state of cytochrome c. The chloride-induced formation of the A-state is a complex reaction with structural intermediates resembling those found under native refolding conditions, including a rapidly formed compact state and a subsequent intermediate with interacting N- and C-terminal helices. Together with mutational evidence for specific helix-helix packing interactions, this shows that the A-state is a stable analogue of a late folding intermediate. The L94A mutation blocks all folding steps after the initial collapse and its equilibrium state resembles early kinetic intermediates.

References

Jan 1, 1992·Annual Review of Biophysics and Biomolecular Structure·J M Scholtz, R L Baldwin
Oct 5, 1991·Journal of Molecular Biology·M F Jeng, S W Englander
Dec 5, 1991·Journal of Molecular Biology·Y Goto, S Nishikiori
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·Y GotoA L Fink
Jul 20, 1990·Journal of Molecular Biology·G W BushnellG D Brayer
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H S Chan, K A Dill
Mar 28, 1972·Biochemistry·J Babul, E Stellwagen
Oct 26, 1995·Nature·V R AgasheJ B Udgaonkar
Apr 29, 1994·Journal of Molecular Biology·V K MisraB Honig
Oct 1, 1995·Nature Structural Biology·J BalbachC M Dobson
Apr 1, 1995·Protein Science : a Publication of the Protein Society·T JordanT G Spiro
Jul 14, 1995·Science·Y BaiS W Englander
Mar 1, 1994·Nature Structural Biology·T R SosnickS W Englander
Apr 1, 1995·Nature Structural Biology·L C WuP S Kim
Mar 14, 1995·Biochemistry·J L Marmorino, G J Pielak
Jan 1, 1995·Sub-cellular Biochemistry·A L Fink
Jul 1, 1994·Current Biology : CB·C M Dobson
Jan 1, 1993·Annual Review of Biochemistry·C R Matthews
Feb 5, 1993·Journal of Molecular Biology·M KataokaY Goto
Jul 13, 1993·Biochemistry·S KhorasanizadehH Roder
Sep 1, 1995·Protein Science : a Publication of the Protein Society·J C AlmagroE Horjales
Jan 1, 1995·Advances in Protein Chemistry·O B Ptitsyn
Jan 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K Kuwajima
May 1, 1996·Nature Structural Biology·M S Kay, R L Baldwin
May 24, 1996·Journal of Molecular Biology·P L Privalov
Jul 1, 1996·Nature Structural Biology·M Jamin, R L Baldwin

❮ Previous
Next ❯

Citations

Dec 29, 1998·Protein Science : a Publication of the Protein Society·M C DemirelI Bahar
Oct 27, 2004·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Paola CaroppiRoberto Santucci
May 26, 2004·Biochimica Et Biophysica Acta·Farah NaseemRizwan Hasan Khan
Mar 19, 2002·Journal of Inorganic Biochemistry·Niels H AndersenJens Ulstrup
Apr 16, 1998·Biochimica Et Biophysica Acta·P Wittung-Stafshede
Feb 1, 1997·Current Opinion in Structural Biology·H Roder, W Colón
Mar 31, 1999·Trends in Biochemical Sciences·R L Baldwin, G D Rose
Mar 11, 2011·Biochemistry·Shigeyoshi NakamuraShun-ichi Kidokoro
May 11, 2006·Chemical Reviews·Heinrich RoderHong Cheng
May 20, 1998·Nature Structural Biology·M C Shastry, H Roder
Mar 25, 2011·Metallomics : Integrated Biometal Science·Md Khurshid Alam KhanFaizan Ahmad
Aug 15, 2001·European Journal of Biochemistry·F SinibaldiR Santucci
Nov 20, 2012·Journal of Biochemistry·Rishu JainRajesh Kumar
Feb 27, 1999·Protein Science : a Publication of the Protein Society·S E RankinT J Pinheiro
Nov 18, 2009·Biochemistry. Biokhimii︠a︡·A NaeemR H Khan
Feb 8, 2005·Applied Bioinformatics·Christopher BystroffXin Yuan
May 27, 2009·International Journal of Molecular Sciences·Robert A GoldbeckDavid S Kliger
Apr 26, 2013·Cellular and Molecular Life Sciences : CMLS·Sobia ZaidiFaizan Ahmad
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·R A StaniforthJ P Waltho
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·T R SosnickS W Englander
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·L C Wu, P S Kim
Dec 25, 2015·The Journal of Physical Chemistry Letters·Nirbhik AcharyaSantosh Kumar Jha
Feb 3, 2009·Microbial Pathogenesis·Dhammika N AtapattuCharles J Czuprynski
Feb 2, 2008·IEEE Transactions on Systems, Man, and Cybernetics. Part B, Cybernetics : a Publication of the IEEE Systems, Man, and Cybernetics Society·M J ZakiC Bystroff
Oct 10, 2006·Journal of Molecular Biology·Rajesh KumarAbani K Bhuyan
Dec 21, 2005·Journal of Molecular Biology·J López-LlanoJ Sancho
May 11, 2005·Biochemical and Biophysical Research Communications·Aabgeena NaeemRizwan Hasan Khan
Jan 15, 2015·Journal of Biomolecular Structure & Dynamics·Abdullah NaiyerFaizan Ahmad
Sep 22, 2009·Journal of Molecular Biology·Heike I Rösner, Christina Redfield
Dec 29, 2012·Current Opinion in Structural Biology·Sanchari Bhattacharyya, Raghavan Varadarajan
Aug 26, 1998·Folding & Design·J M Sauder, H Roder
Jul 6, 2016·International Journal of Biological Macromolecules·Sabab Hasan KhanFaizan Ahmad
Apr 6, 2017·The FEBS Journal·Joseline A Houwman, Carlo P M van Mierlo
Feb 19, 1998·Journal of Molecular Biology·J L MarmorinoG J Pielak
Dec 3, 2014·International Journal of Biological Macromolecules·Md Anzarul HaqueFaizan Ahmad
Mar 12, 2009·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Md Khurshid Alam KhanFaizan Ahmad
Oct 17, 2012·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Matthieu SimonArnaud Bondon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.