Kinetic modeling and long-term test-retest reproducibility of the mGluR5 PET tracer 18F-FPEB in human brain

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Gil Leurquin-SterkKoen Van Laere

Abstract

(18)F-FPEB is a promising PET tracer for studying the metabotropic glutamate subtype 5 receptor (mGluR5) expression in neuropsychiatric disorders. To assess the potential of (18)F-FPEB for longitudinal mGluR5 evaluation in patient studies, we evaluated the long-term test-retest reproducibility using various kinetic models in the human brain. Nine healthy volunteers underwent consecutive scans separated by a 6-month period. Dynamic PET was combined with arterial sampling and radiometabolite analysis. Total distribution volume (V(T)) and nondisplaceable binding potential (BP(ND)) were derived from a two-tissue compartment model without constraints (2TCM) and with constraining the K(1)/k(2) ratio to the value of either cerebellum (2TCM-CBL) or pons (2TCM-PONS). The effect of fitting different functions to the tracer parent fractions and reducing scan duration were assessed. Regional absolute test-retest variability (aTRV), coefficient of repeatability (CR) and intraclass correlation coefficient (ICC) were computed. The 2TCM-CBL showed best fits. The mean 6-month aTRV of V(T) ranged from 8 to 13% (CR < 25%) with ICC > 0.6 for all kinetic models. BPND from 2TCM-CBL with a sigmoid fit for the parent fractions showed the best reproduc...Continue Reading

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Citations

Oct 16, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Christine DeLorenzoIrina Esterlis
Nov 28, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Geoffrey WarnockSimon M Ametamey
Aug 2, 2019·Brain Sciences·Chelsea R KastenTiffany A Wills
Jan 20, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Gil Leurquin-SterkKoen Van Laere
Sep 5, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jenny CeccariniKoen Van Laere
Nov 3, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Gil Leurquin-SterkKoen Van Laere
Jul 30, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Gil Leurquin-SterkMark E Schmidt
May 21, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hayel TuncelSandeep Sv Golla

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