Kinetic modeling of 68 Ga-PSMA-11 and validation of simplified methods for quantification in primary prostate cancer patients

EJNMMI Research
Anna RingheimRonaldo Hueb Baroni

Abstract

The positron emission tomography (PET) ligand 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) targets the prostate-specific membrane antigen (PSMA), upregulated in prostate cancer cells. Although 68Ga-PSMA-11 PET is widely used in research and clinical practice, full kinetic modeling has not yet been reported nor have simplified methods for quantification been validated. The aims of our study were to quantify 68Ga-PSMA-11 uptake in primary prostate cancer patients using compartmental modeling with arterial blood sampling and to validate the use of standardized uptake values (SUV) and image-derived blood for quantification. Fifteen patients with histologically proven primary prostate cancer underwent a 60-min dynamic 68Ga-PSMA-11 PET scan of the pelvis with axial T1 Dixon, T2, and diffusion-weighted magnetic resonance (MR) images acquired simultaneously. Time-activity curves were derived from volumes of interest in lesions, normal prostate, and muscle, and mean SUV calculated. In total, 18 positive lesions were identified on both PET and MR. Arterial blood activity was measured by automatic arterial blood sampling and manual blood samples were collected for plasma-to-blood ratio correction and for metabolite analysis. The analysis...Continue Reading

References

Mar 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C S PatlakJ D Fenstermacher
Feb 3, 2004·Journal of Cellular Biochemistry·Arundhati Ghosh, Warren D W Heston
May 25, 2011·Proceedings of the National Academy of Sciences of the United States of America·Michael J EvansCharles L Sawyers
Aug 16, 2011·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Giampaolo TomasiEric Aboagye
Sep 28, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Ali Afshar-OromiehUwe Haberkorn
Jan 1, 2013·Contemporary Oncology Współczesna Onkologia·Elżbieta Luczyńska, Joanna Anioł
Feb 14, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Eline E VerwerRonald Boellaard
Oct 3, 2015·European Urology·Jeffrey C WeinrebSadna Verma
Jan 13, 2016·European Journal of Nuclear Medicine and Molecular Imaging·C SachpekidisA Dimitrakopoulou-Strauss
May 22, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Christian H PfobMatthias Eiber
Jun 5, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Ali Afshar-OromiehUwe Haberkorn
Oct 18, 2016·Clinical Nuclear Medicine·Christos SachpekidisAntonia Dimitrakopoulou-Strauss
Mar 12, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Wolfgang P FendlerKen Herrmann
Apr 13, 2017·Nuklearmedizin. Nuclear Medicine·Susanne LütjeAxel Wetter
Dec 7, 2017·EJNMMI Physics·Sandeep S V GollaRonald Boellaard

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Software Mentioned

MathWorks
R
MATLAB
syngo
PSAMPLE
via
Prostate Imaging Reporting and Data System
R Core Team

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.