Kinetic modelling and residue depletion of drugs in eggs

British Poultry Science
P Hekman, G J Schefferlie

Abstract

1. A physiologically-based pharmacokinetic model was developed for the purpose of describing the relationship between plasma concentration of drugs and their deposition into eggs. 2. By incorporating the physiology of egg formation into the model, the transfer of drugs into the egg albumen and yolk could be described using rate constants. 3. The model was used to describe concentrations in albumen and yolk of sulphanilamide, sulphaquinoxaline and pyrimethamine as a function of time using datasets from the literature. 4. The model could be used as a tool to obtain an insight into those properties of a drug which are responsible for the amount of residue in eggs, and could help in the design of critical studies for determining withdrawal periods for eggs.

References

May 1, 1977·Poultry Science·H OikawaK Katagiri
Sep 1, 1990·British Poultry Science·B Roudaut, J P Moretain
Jul 1, 1987·Food Additives and Contaminants·B RoudautJ Boisseau
Jul 1, 1972·Poultry Science·H J LaurencotJ L Hempstead
Aug 1, 1983·Journal of Pharmacobio-dynamics·K Yamaoka, T Nakagawa
Jan 16, 2001·Journal of Agricultural and Food Chemistry·C A Kan, M Petz
Jan 16, 2001·Journal of Agricultural and Food Chemistry·P S ChuB Shaikh
Feb 13, 2001·Journal of Veterinary Pharmacology and Therapeutics·M GiorgiG Mengozzi

Citations

Sep 12, 2012·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·V VandenbergeE Daeseleire
Jan 15, 2016·Journal of Veterinary Pharmacology and Therapeutics·G J Schefferlie, P Hekman
Aug 19, 2015·BMC Veterinary Research·S Al-Shahrani, V Naidoo
Aug 2, 2014·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Teresa L LeavensJim E Riviere
May 24, 2014·Journal of Food Protection·Rubén MuñozBetty San Martín
Dec 9, 2020·Journal of Veterinary Pharmacology and Therapeutics·Yu-Shin WangZhoumeng Lin

Related Concepts

Azol Polvo
Egg Whites
Egg Yolk (Dietary)
Egg Food Product
Fowls, Domestic
Malocide
Sulfanilamides
Sulfaquinoxaline
Literature
Plasma

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