Kinetic models for enzymic cellulose degradation in aqueous two-phase systems

Biotechnology and Bioengineering
C F MandeniusF Tjerneld


Cellulose materials can readily be degraded into cellobiose and glucose by hydrolysis of the enzymes cellulase and beta-glucosidase in aqueous media. Product inhibition does, however, retard the reaction rate and reduce productivity. This may be avoided by carrying out the degradation of cellulose in an aqueous two-phase system, which permits the enzymes and the substrate to be partitioned to one phase and the products to be extracted into a second phase. In addition, two-phase systems also allow recycling of the enzymes. Here, three models previously developed for "one-phase" enzymic degradation are compared to data from enzymic degradation in an aqueous two-phase system. The models tested agreed relatively well with batch experiments during a period of 200 h. For one of the models tested, continuous degradation also gave accurate agreement.


Jul 1, 1977·Biotechnology and Bioengineering·C S GongG T Tsao
Mar 1, 1984·Biotechnology and Bioengineering·S WaldH W Blanch
Jul 1, 1984·Biotechnology and Bioengineering·M T HoltzappleA E Humphrey

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