Sep 1, 1979

Kinetic patterns of their reactions catalyzed by membrane-bound monoamine oxidase

Biokhimii︠a︡
L G Vasil'evykhZ S Kagan

Abstract

The initial rate (v) versus initial substrate concentration [S]0 plots for the reaction of serotonin deamination catalyzed by rat liver mitochondrial monoamine oxidase are characterized by complicated non-hyperbolic patterns. The shapes of the curves in the plots depend on the age and strain of the animals used or on alterations in the physico-chemical state of mitochondria caused by freezing -- thawing and swelling in hypotonic solutions. The v versus [S]0 plots for other substrates (e. g. tyramine) do not obey the Michaelis -- Menten equation as well. In order to interpret the kinetic patterns described a model of the mitochondrial monoamine oxidase structure and function has been proposed. The model is based on the assumption that both catalytic and regulatory allosteric sites are present on the surface of monoamine oxidase molecules. In the process of serotonin or tyramine binding the monoamine oxidases exhibit cooperative properties which are characteristic for the allosteric enzymes. The model also suggests an active regulatory role of the mitochondrial membrane itself.

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Paraparesis
Allosteric Site
Enzymes, antithrombotic
Serotonin Measurement
Serotonin
Monoamine Oxidase [PK]
Mitochondrial Membranes
Mitochondria, Liver
Etiology
Monoamine Oxidase

About this Paper

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

IGA Glomerulonephritis

IgA glomerulonephritis is a chronic form of glomerulonephritis characterized by deposits of predominantly Iimmunoglobin A in the mesangial area. Discover the latest research on IgA glomerulonephritis here.

Cryogenic Electron Microscopy

Cryogenic electron microscopy (Cryo-EM) allows the determination of biological macromolecules and their assemblies at a near-atomic resolution. Here is the latest research.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

LRRK2 & Immunity During Infection

Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. However, LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Here is the latest research on the role of this kinase on immunity during infection.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Meningococcal Myelitis

Meningococcal myelitis is characterized by inflammation and myelin damage to the meninges and spinal cord. Discover the latest research on meningococcal myelitis here.

Alzheimer's Disease: MS4A

Variants within membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease by recent genome-wide association studies. Here is the latest research.