PMID: 1206432Dec 1, 1975Paper

Kinetic studies on glial, Schwann and capsular cells labelled with [3H] thymidine in cerebrospinal tissue of young mice

Journal of the Neurological Sciences
R Kraus-RuppertN Odartchenko

Abstract

Neuroglia, capsular and Schwann cell renewal and turnover in the cerebellum, the spinal cord and spinal ganglia have been evaluated in 2-months-old mice. The animals received intraperitoneal injections of [3H] thymidine at 8 hr intervals starting on the 28th day of postnatal life for a period of 30 days and were killed 1 hr after the last injection. Substantial numbers of labelled neuroglial cells but no labelled neurons were observed. Oligodendrocytes of the cerebellum and the spinal cord showed higher labelling indices (19.8% and 18.0%, respectively) than astrocytes (10.0%) and Bergmann's supporting cells (7.2%). The labelling indices of capsular cells in the spinal ganglia and Schwann cells in the spinal roots were 35.8% and 25.8%, respectively. The experiments failed to provide evidence for matrix cell layers in the cerebellum, the spinal cord and spinal ganglia. It may be concluded therefore that glial and Schwann cells in these parts of the nervous system proliferate in situ.

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Citations

Jun 1, 1979·Journal of Neurocytology·S N Lawson, T J Biscoe
Apr 1, 1985·Brain Research·J E BruniR E Clattenburg
Sep 13, 2001·The European Journal of Neuroscience·A RepresaS Weiss
Jul 26, 2008·Stem Cells and Development·Mercy VargheseIver A Langmoen
Dec 25, 2003·The Journal of Comparative Neurology·Ivonne Vidal PizarroMichael E Selzer
Jan 24, 1998·Experimental Neurology·L S ShihabuddinF H Gage
Apr 29, 1998·Microscopy Research and Technique·J E Bruni
Nov 15, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Iris KulbatskiCharles H Tator
Feb 1, 1979·The American Journal of Anatomy·R H Rhodes
Feb 13, 2003·Journal of Neuropathology and Experimental Neurology·Masaki TakahashiShunichi Shirai

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