Kinetics and anthelmintic efficacy of topical eprinomectin when given orally to goats

Veterinary Parasitology
C BadieChristophe Chartier

Abstract

Preliminary data suggest that topical eprinomectin in goat shows an individual variation in anthelmintic efficacy when used off-license at a dose rate of 0.5 or 1.0mg/kg BW. As a result, the use of oral administration of topical formulation of eprinomectin tends to develop in dairy goat farms in France. The plasma levels and milk excretion as well as the anthelmintic efficacy of eprinomectin were determined in goats following oral administration of a topical formulation of the drug at dose rates of 0.5 and 1mg/kg BW. The area under the concentration-time curve (AUC) values were 17.62 ± 9.68 ng day/ml and 6.56 ± 4.00 ng day/ml for plasma and milk respectively after the administration of 0.5mg/kg BW and 45.32 ± 13.90 ng day/ml and 13.88 ± 1.77 ng day/ml for plasma and milk, respectively after the administration of 1mg/kg BW. The milk-to-plasma ratio ranged from 0.33 to 0.36 and the amount of drug recovered in the milk was 0.4% of the total administered dose. The maximum concentrations of eprinomectin residues determined in milk after oral treatment were < 20 μg/kg (Maximum Residue Limit in goat milk). The anthelmintic efficacy of the oral administration of topical eprinomectin was 100% through Faecal Egg Count Reduction Test in n...Continue Reading

References

May 18, 2001·Parasitology Research·J DupuyM Alvinerie
Dec 19, 2002·Parasitology Research·A LespineM Alvinerie
Oct 13, 2006·Parasitology Research·Ana Carolina de Souza ChagasLuciana Cristine Vasques Villela
May 5, 2009·The Veterinary Record·C ParaudC Chartier
Feb 16, 2010·Parasitology Research·Carine ParaudChristophe Chartier
Jan 15, 2011·International Journal for Parasitology·Alain Bousquet-MélouPierre-Louis Toutain
Aug 12, 2014·Parasitology Research·Steffen RehbeinTeresa A Wehner

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Citations

Jul 25, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Leyla Polat KoseClaudiu T Supuran

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Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.