PMID: 6538162Feb 1, 1984Paper

Kinetics and bioavailability of N-nitrosodiethanolamine after intravenous and cutaneous administration to rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
L AiroldiR Fanelli

Abstract

Male CD-COBS rats were given N-nitrosodiethanolamine (NDELA) by intravenous or cutaneous administration at a dose of 5 mg/kg. Blood and liver were analysed for NDELA at various times after administration. The excretion of unchanged NDELA and its acidic metabolite N-(2-hydroxyethyl)-N-carboxymethylnitrosamine (ECMN) was determined in urine for 24 hr after treatment. The semilogarithmic blood concentration-time plot after iv injection showed a triphasic profile indicating that a three-compartment model may adequately describe the kinetics of this compound. After cutaneous application NDELA was rapidly absorbed through the skin, and the absolute bioavailability was calculated to be 27% from blood data, and to be 32% (NDELA + ECMN) from urine data. Hepatic NDELA levels reflected blood levels after both treatments, indicating that this organ does not accumulate NDELA to a significant extent. Urinary excretion of unchanged NDELA after iv and cutaneous administration was 83 and 25% of the administered dose, respectively. ECMN excretion was 4.9 and 2.5% of the administered dose after iv and cutaneous administration, respectively.

References

Oct 1, 1977·Food and Cosmetics Toxicology·T Y FanK Biemann
Jan 1, 1974·Drug Metabolism Reviews·M Gibaldi, D Perrier
May 1, 1983·Biomedical Mass Spectrometry·L AiroldiR Fanelli
Aug 1, 1982·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E J LethcoE Brouwer
Dec 11, 1980·Nature·W LijinskyW B Manning

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Citations

Nov 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M BonfantiL Airoldi
Mar 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E Kamp, G Eisenbrand
May 21, 2005·Regulatory Toxicology and Pharmacology : RTP·Shakil A SaghirWilliam T Stott
Mar 1, 1985·Cancer Letters·B Löfberg, H Tjälve
Mar 5, 1999·Drug Metabolism Reviews·R N Loeppky
Dec 14, 2005·Toxicology and Industrial Health·Ronald E BaynesJim E Riviere

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