Kinetics and cellular sources of cathelicidin during the course of experimental latent tuberculous infection and progressive pulmonary tuberculosis.

Clinical and Experimental Immunology
Julio E Castañeda-DelgadoBruno Rivas-Santiago

Abstract

In spite of advances in immunology on mycobacterial infection, there are few studies on the role of anti-microbial peptides in tuberculosis. The cathelin-related anti-microbial peptide (CRAMP) is the only cathelicidin isolated from mice. In this work we investigated the cellular sources and the production kinetics of this molecule during experimental tuberculosis, using two well-characterized models of latent or chronic infection and progressive disease. The lung of non-infected control mice expressed CRAMP at very low levels. In both models of experimental tuberculosis the main cells immunolabelled for CRAMP were bronchial epithelial cells, macrophages and pneumocytes types II and I. After intratracheal infection with a high bacilli dose (H37Rv strain) in Balb/c mice to produce progressive disease, a high CRAMP gene expression was induced showing three peaks: very early after 1 day of infection, at day 21 when the peak of protective immunity in this model is raised, and at day 28 when the progressive phase starts and the immunoelectronmicroscopy study showed intense immunolabelling in the cell wall and cytoplasm of intracellular bacilli, as well as in cytoplasmic vacuoles. Interestingly, at day 60 post-infection, when advanced...Continue Reading

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Citations

Mar 2, 2013·Cell Communication and Signaling : CCS·Selvakumar SubbianGilla Kaplan
Oct 4, 2013·Immunotherapy·Cesar Enrique Rivas-SantiagoBruno Rivas-Santiago
Mar 23, 2013·Annual Review of Immunology·Anne O'GarraMatthew P R Berry
Nov 18, 2014·Immunity, Inflammation and Disease·José Carlos SantosRui Appelberg
Jun 14, 2013·Clinical & Developmental Immunology·Koen Vanden DriesscheKevin B Urdahl
Nov 13, 2012·International Journal of Antimicrobial Agents·Bruno Rivas-SantiagoRogelio Hernandez-Pando
Dec 3, 2014·Seminars in Immunology·Anca Dorhoi, Stefan H E Kaufmann
Mar 27, 2018·Expert Review of Respiratory Medicine·Octavio Ramos-EspinosaRogelio Hernández-Pando
Sep 10, 2015·Infection and Immunity·Flor Torres-JuarezBruno Rivas-Santiago
Nov 1, 2016·Biomedit︠s︡inskai︠a︡ khimii︠a︡·D S EsmedlyaevaV Y Zhuravlev
Jan 6, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Allison E Reeme, Richard T Robinson
Mar 9, 2021·Journal of Leukocyte Biology·Octavio Ramos-EspinosaRogelio Hernández-Pando
Dec 3, 2020·Tuberculosis·Claudia Valdez MiramontesBruno Rivas-Santiago

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