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Kinetics and mechanisms of hydrolysis of 1,4-benzodiazepines II: oxazepam and diazepam

Journal of Pharmaceutical Sciences

Apr 1, 1977

W W HanD D Maness

PMID: 16116

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Abstract

The hydrolysis kinetics of oxazepam and diazepam leading to a benzophenone product and a glycine derivative were quantified from pH 1 to 11. For oxazepam, two intermediates were isolated and identified, indicating a parallel consecutive reaction mechanism. The hydrolysis occurred uncata...read more

Mentioned in this Paper

Benzophenone
Thermodynamics
Amides
Glycine
Glycine (Plant)
Azomethine
Diazepam
Tazepam
Spectrophotometry
Benzodiazepines Assay
Paper Details
References
  • References2
  • Citations11
1
  • References2
  • Citations11
12

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Kinetics and mechanisms of hydrolysis of 1,4-benzodiazepines I: chlordiazepoxide and demoxepam

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Kinetics and mechanisms of hydrolysis of 1,4-benzodiazepines II: oxazepam and diazepam

Journal of Pharmaceutical Sciences

Apr 1, 1977

W W HanD D Maness

PMID: 16116

DOI:

Abstract

The hydrolysis kinetics of oxazepam and diazepam leading to a benzophenone product and a glycine derivative were quantified from pH 1 to 11. For oxazepam, two intermediates were isolated and identified, indicating a parallel consecutive reaction mechanism. The hydrolysis occurred uncata...read more

Mentioned in this Paper

Benzophenone
Thermodynamics
Amides
Glycine
Glycine (Plant)
Azomethine
Diazepam
Tazepam
Spectrophotometry
Benzodiazepines Assay

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Related Papers

Journal of Pharmaceutical Sciences

Kinetics and mechanisms of hydrolysis of 1,4-benzodiazepines I: chlordiazepoxide and demoxepam

Journal of Pharmaceutical SciencesAugust 1, 1976
W W HanD D Maness
Journal of Pharmaceutical Sciences

Kinetics and mechanisms of hydrolysis of 1,4-benzodiazepines III: nitrazepam

Journal of Pharmaceutical SciencesJune 1, 1977
W W HanD D Maness
Paper Details
References
  • References2
  • Citations11
1
  • References2
  • Citations11
12

Download from

PubMed
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