journal cover

Kinetics and mechanisms of hydrolysis of 1,4-benzodiazepines III: nitrazepam

Journal of Pharmaceutical Sciences

Jun 1, 1977

W W HanD D Maness

PMID: 17718

Download from

PubMed

Abstract

The hydrolysis of nitrazepam involves a two-step sequential mechanism. The intermediate is the ring-opened compound resulting from scission of the azomethine bond. The final products are glycine and 2-amino-5-ni-robenzophenone. Recyclization of the intermediate to nitrazepam occurs at p...read more

Mentioned in this Paper

Thermodynamics
Phosphate buffers
Amides
Imeson
Glycine
Glycine (Plant)
Azomethine
Spectrophotometry, Ultraviolet
Spectrophotometry
Drug Stability
Paper Details
References
  • References
  • Citations9
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations9
1

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Asperger Syndrome

Asperger syndrome (AS), also known as Asperger's, is a developmental disorder characterized by significant difficulties in social interaction and nonverbal communication, along with restricted and repetitive patterns of behavior and interests. Discover the latest research on Asperger syndrome here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Coccidioidomycosis

Coccidioidomycosis is a fungal disease caused by Coccidioides immitis and Coccidioides posadasii. Symptoms include fever, cough and coin lesions. Discover the latest research on Coccidioidomycosis here.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Omics in Myocardial Infarction

Omics' methods are used to understand the gene expression profile and proteomics of many diseases. This feed focuses on omics analyses of myocardial infarction. Here are the latest discoveries pertaining to this disease.

COVID-19 & Diabetes (ADA)

COVID-19 (short for “Coronavirus Disease 2019") is the disease caused by the novel coronavirus, SARS-CoV-2. Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. COVID-19 represents a particular challenge to people with serious chronic medical conditions such as diabetes. To keep our community as informed as possible, the American Diabetes Association is partnering with the Chan Zuckerberg Initiative's Meta to highlight the latest research developments at the intersection of COVID-19 and diabetes.

Severe Acute Respiratory Syndrome

Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin caused by the SARS coronavirus (SARS-CoV). Initial symptoms are flu-like and may include fever, muscle pain, lethargy symptoms, cough, sore throat, and other nonspecific symptoms. SARS may eventually lead to shortness of breath and pneumonia; either direct viral pneumonia or secondary bacterial pneumonia. DIscover the latest research on SARS here.

Related Papers

Journal of Pharmaceutical Sciences

Kinetics and mechanisms of hydrolysis of 1,4-benzodiazepines II: oxazepam and diazepam

Journal of Pharmaceutical SciencesApril 1, 1977
W W HanD D Maness
Journal of Pharmaceutical Sciences

Kinetics and mechanisms of hydrolysis of 1,4-benzodiazepines I: chlordiazepoxide and demoxepam

Journal of Pharmaceutical SciencesAugust 1, 1976
W W HanD D Maness
© 2020 Meta ULC. All rights reserved

Kinetics and mechanisms of hydrolysis of 1,4-benzodiazepines III: nitrazepam

Journal of Pharmaceutical Sciences

Jun 1, 1977

W W HanD D Maness

PMID: 17718

DOI:

Abstract

The hydrolysis of nitrazepam involves a two-step sequential mechanism. The intermediate is the ring-opened compound resulting from scission of the azomethine bond. The final products are glycine and 2-amino-5-ni-robenzophenone. Recyclization of the intermediate to nitrazepam occurs at p...read more

Mentioned in this Paper

Thermodynamics
Phosphate buffers
Amides
Imeson
Glycine
Glycine (Plant)
Azomethine
Spectrophotometry, Ultraviolet
Spectrophotometry
Drug Stability

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Related Papers

Journal of Pharmaceutical Sciences

Kinetics and mechanisms of hydrolysis of 1,4-benzodiazepines II: oxazepam and diazepam

Journal of Pharmaceutical SciencesApril 1, 1977
W W HanD D Maness
Journal of Pharmaceutical Sciences

Kinetics and mechanisms of hydrolysis of 1,4-benzodiazepines I: chlordiazepoxide and demoxepam

Journal of Pharmaceutical SciencesAugust 1, 1976
W W HanD D Maness
Paper Details
References
  • References
  • Citations9
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations9
1

Download from

PubMed
/papers/kinetics-and-mechanisms-of-hydrolysis-of-14-benzod/17718