PMID: 1202363Nov 21, 1975Paper

Kinetics and metabolism of amphetamine in the brain of rats of different ages

Naunyn-Schmiedeberg's Archives of Pharmacology
H Honecker, H Coper

Abstract

The kinetics and tissue distribution of amphetamine and its metabolites p-hydroxyamphetamine (p-PH-A) and p-hydroxynorephedrine (p-OH-NE) were investigated in young adult (3-4 months) and old (20-25 months) male rats, after i.p. injection of 5 mg/kg tritium labelled D-amphetamine. The concentrations of these drugs were determined in plasma, cerebral cortex, brainstem and hypothalamus, by thin layer chromatography. 1. From 60 min up to 4 hrs after injection of amphetamine the concentration of amphetamine in plasma and brain tissue of old rats was significantly (P less than 0.05 higher than in young adult animals. In both age groups the levels of amphetamine in cerebral cortex greater than brain stem greater than hypothalamus. 2. The blood-brain barrier is permutle to p-OH-A; 10 to 20 min afer i.v. injection of 10 muCi/kg of p-OH-A (10 mCi/m mole) the ratio of brain/blood plasma was found to be 1:3. The half life of p-OH-A in blood plasma was almost identical after injection of amphetamine and p-OH-A (90 min and 98 min respectively). 3. The levels of p-OH-NE in different brain areas were significantly lower (P less than 0.05) in old animals than in young adult rats 4 hrs after application of amphetamine. This metabolite of amphet...Continue Reading

References

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Citations

May 27, 2011·Neuroscience Bulletin·Normand Carrey, Michael Wilkinson
Feb 1, 1978·Biochemical Pharmacology·C M KuhnG R Breese
Mar 1, 1986·Pharmacology, Biochemistry, and Behavior·N O SteinerW Isaac
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May 24, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Erin S Calipari, Mark J Ferris
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Nov 2, 2014·The European Journal of Neuroscience·David J RademacherGloria E Meredith
Feb 2, 2011·Pharmacology, Biochemistry, and Behavior·Morgana MorettiJoão Quevedo
Oct 19, 2012·Journal of Psychopharmacology·Kelen Cechinel-ReccoJoão Quevedo
Jan 1, 1994·Documenta Ophthalmologica. Advances in Ophthalmology·P Theiss, O J Grüsser
Jan 1, 1984·Experimental Gerontology·B Jänicke, D Wrobel

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