Kinetics and quantification of antibacterial effects of beta-lactams, macrolides, and quinolones against gram-positive and gram-negative RTI pathogens

Infection
K-J SchaperA Dalhoff

Abstract

Traditionally, the in vitro activity of antibacterial agents is characterized by their minimal inhibitory concentrations. However, these endpoints are, by nature, discrete and do not provide information on time-dependent killing of the bacteria during the incubation period. Nevertheless, the pharmacodynamic characteristics of antibacterial agents are almost always defined by correlating a static endpoint describing the antibacterial activity of an agent with the pharmacokinetics, describing the time-dependent fluctuation of drug concentrations. This approach is basically a contradiction in itself. Therefore, it would be more logical to correlate pharmacokinetics to in vitro parameters describing the time- and concentration-dependent antibacterial action of an agent. Thus, experimental methods and mathematical models quantifying the decrease in growth rate of a bacterial population due to the action of an antibacterial agent as a function of time and drug concentration have been applied to quantitate their pharmacodynamics. The effect of nine antibacterial agents representing drug classes of penicillins, cephalosporins, penems, macrolides, and fluoroquinolones were mathematically analyzed by using three different but related mod...Continue Reading

Citations

May 21, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T KosakaN Fujita
Jul 16, 2010·International Journal of Antimicrobial Agents·Axel Dalhoff, Sabine Schubert
Dec 5, 2006·Diagnostic Microbiology and Infectious Disease·Sudha PottumarthyRonald N Jones
Nov 25, 2014·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Kristen E GibsonLona Mody
Jan 4, 2008·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Gary A NoskinMurtuza Bharmal
Oct 7, 2010·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Bruce Y LeeLee M Harrison
Jun 30, 2016·Antimicrobial Agents and Chemotherapy·Marguerite L MonogueDavid P Nicolau
Jun 15, 2006·Expert Review of Anti-infective Therapy·Francesco Scaglione, Luca Paraboni

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