Kinetics effects and modeling of mRNA turnover

Wiley Interdisciplinary Reviews. RNA
Maria Concetta PalumboPaola Paci

Abstract

Broader comprehension of gene expression regulatory mechanisms can be gained from a global analysis of how transcription and degradation are coordinated to orchestrate complex cell responses. The role of messenger RNA (mRNA) turnover modulation in gene expression levels has become increasingly recognized. From such perspective, in this review we briefly illustrate how a simple but effective mathematical model of mRNA turnover and some experimental findings, may together shed light on the molecular mechanisms underpinning the major role of mRNA decay rates in shaping the kinetics of gene activation and repression.

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Jun 14, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Laura P M H de RooijKristin J Hope
Dec 7, 2017·RNA Biology·Victor N Ierusalimsky, Pavel M Balaban
Mar 9, 2019·Wiley Interdisciplinary Reviews. RNA·Sarah A PeckAmber L Mosley
Apr 3, 2020·Life Science Alliance·Akinori TakahashiTadashi Yamamoto
Oct 3, 2018·Wiley Interdisciplinary Reviews. RNA·Toshimichi Yamada, Nobuyoshi Akimitsu

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