PMID: 231454Jan 1, 1978

Kinetics of 5--nucleotidase in sera of liver cirrhotic and normal Iraqi individuals

Biochemistry and Experimental Biology
S A Al-Mudhaffar, V Saadalla

Abstract

5'-Nucleotidase activity was elevated in patients with liver cirrhosis; greater values of 5'-Nucleotidase activity were found in biliary cirrhosis, 5'-Nucleotidase from liver cirrhotic sera was less stable than from normal sera. The velocity of 5'Nucleotidase from liver cirrhotic sera per minute, at t = 10, was greater than normal controls. The optimum (S) for 5'-Nucleotidase was found to be 1.0 mM A-5'-MP, for both normal and liver cirrhotic sera. Km (A-5'-MP) and (2'-d-A-5'-MP) of 5'-Nucleotidase was found to be significantly lower in patients with liver cirrhosis than normal controls.

Related Concepts

Fibrosis, Liver
Nucleotidases
5'-NUCLEOTIDASE

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