PMID: 10419Aug 1, 1976

Kinetics of acid neutralization by aluminum hydroxide gel

Journal of Pharmaceutical Sciences
S L NailS L Hem

Abstract

The rate of acid neutralization by an aluminum hydroxide gel prepared by the reaction of aluminum chloride solution and strong ammonia solution was studied. The decrease in acid-consuming capacity during aging as measured by the USP test is due to a decrease in the rate of reaction rather than to a decrease in equilibrium reactivity. The reactivity profile has three phases, which are shown to be related to the structure of the gel. The rate of loss of reactivity is directly related to the extent of washing.

References

Jul 1, 1975·Journal of Pharmaceutical Sciences·S L NailS L Hem
Mar 1, 1970·Journal of Pharmaceutical Sciences·S L HemR S Levi

Citations

Apr 6, 2006·AAPS PharmSciTech·Alessandro GainottiPasquale Del Gaudio
Mar 1, 2006·AAPS PharmSciTech·Alessandro GainottiPasquale Del Gaudio

Related Concepts

Alhydrogel
Ammonia
Chloride Ion Level
Hydrogen-Ion Concentration

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