PMID: 319659Feb 1, 1977

Kinetics of atropine inhibition of pentagastrin-stimulated H+, electrolyte, and pepsin secretion in the dog

The American Journal of Digestive Diseases
B I Hirschowitz, G A Hutchison

Abstract

The effects of atropine on pentagastrin-stimulated gastric secretion of water, H, Cl, Na, K, and pepsin were determined by kinetic analysis of dose-response studies in 5 dogs with esophagostomy and gastric cannula. First a dose-response study was done using 7 doses of pentagastrin (1-6 mug/kg hr), each dose given by I.V. infusion for 4 hr at a separate time. The same series of doses was used with atropine sulfate 10 mug/kg hr as background. Atropine inhibited pentagastrin-stimulated secretion competively with a dose ratio change of 20. In a third set of studies pentagastrin was infused alone for 4 hrs in the dose of 1.5 mug/kg hr and then with each of 7 doses of atropine (0.625-40 mug/kg hr), each dose used separately. Atropine competitively inhibited water, H, Cl, and K secretion, with Ki (dose of atropine giving 50% inhibition) of 1.0 mug/kg hr. Pepsin secretion was much more strongly inhibited than acid secretion by atropine with Ki 0.27 mug/kg hr and the inhibition was uncompetitive. Calculated maximal inhibition of H+ secretion by atropine was 89% and of pepsin 95%. Furthermore the shape of the response to pentagastrin was altered by atropine so that the peak response was delayed to the third and fourth hour of pentagastri...Continue Reading

References

Aug 31, 1979·World Journal of Surgery·A H Soll
Mar 1, 1984·The Japanese Journal of Surgery·T TokunagaM Akagi
Nov 1, 1984·Postgraduate Medical Journal·B I Hirschowitz
May 1, 1984·The Journal of Clinical Investigation·A H SollJ D Elashoff
Dec 12, 1981·The Journal of Applied Behavioral Science·L Greenhalgh

Citations

May 1, 1972·The American Journal of Physiology·B I HirschowitzG Sachs
May 14, 1971·Nature·H P Rang
Jan 1, 1968·Digestion·J A Ritchie
Mar 1, 1969·The American Journal of Physiology·G A Hutchison, B I Hirschowitz
Aug 1, 1961·The Biochemical Journal·G N WILKINSON

Related Concepts

Chloride Ion Level
Electrolytes
Potassium
Structure of Pyloric Gland
Ions
Hydrogen
Pepsin 1
Sodium
Peptavlon
Stomach Diseases

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