PMID: 6991920Mar 1, 1980Paper

Kinetics of benzo[a]pyrene induced mutagenesis in a highly sensitive salmonella/microsome assay

Mutation Research
J Unger, J B Guttenplan

Abstract

The kinetics of benzo[a]pyrene induced mutagenesis in Salmonella typhimurium TA98 and TA100 were studied using a liquid-phase assay and were compared to kinetics of metabolism of benzo[a]pyrene in the same system. Mutagenesis was terminated by the addition of pyrene + menadione at selected times. Under conditions of the assay using hepatic microsomes from 3-methyl-cholanthrene pretreated rats, metabolism of benzo[a]pyrene was over 50% complete in 5 min, and metabolism of initial metabolites became appreciable after this time. The revertant frequency (revertants/10(8) survivors) and the production of tertiary metabolites increased sharply after 5 min and leveled off at 40 min.

References

Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Dec 1, 1977·Mutation Research·T Tang, M A Friedman
Mar 15, 1979·International Journal of Cancer. Journal International Du Cancer·R A LubetR A Prough
Feb 9, 1979·Science·F J de Serres, M D Shelby
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames

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Citations

Nov 1, 1982·Environmental Health Perspectives·J L Seed
Apr 16, 2013·FEMS Microbiology Letters·Hani A Alhadrami, Graeme I Paton
Jan 1, 1980·Teratogenesis, Carcinogenesis, and Mutagenesis·G C Forti, N M Trieff
Sep 1, 1987·Mutation Research·J B Guttenplan

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