Kinetics of CBD, Δ9-THC Degradation and Cannabinol Formation in Cannabis Resin at Various Temperature and pH Conditions.

Cannabis and Cannabinoid Research
Wuttichai JaideeNeti Waranuch

Abstract

Introduction: Cannabidiol (CBD), cannabinol (CBN), and Δ9-tetrahydrocannabinol (Δ9-THC) are major cannabinoids in cannabis resin and products. The kinetic of the chemical reaction of resin cannabis is important for product development and storage. A few reports are available in the literature on the rate of CBD and Δ9-THC degradation, and CBN formation in dried resin and solutions of various pH. Materials and Methods: Thermal degradation of CBD, Δ9-THC, and formation of CBN was studied at 50°C, 60°C, 70°C, and 80°C for dried cannabis resin. The effect of pH and temperature on cannabinoids transformation in cannabis solution was also examined at pH 2, 4, 6, 8, 10, and 12 and at 40°C, 50°C, 60°C, and 70°C. High-performance chromatography coupled with diode-array detection (HPLC-DAD) was used for the analysis of CBD, CBN, and Δ9-THC transformation. The values of activation energies (Ea), shelf-life (t90% - t110%), and rate constant (k) were calculated for the CBD, Δ9-THC, and CBN. The effect of temperature and pH on the dried cannabis resin was adequately modeled with the Arrhenius equation. Results: The results indicated that the chemical kinetics in the thermal degradation of CBD, Δ9-THC, and formation of CBN were the zero-order...Continue Reading

References

May 1, 1977·The Journal of Pharmacy and Pharmacology·R N Smith, C G Vaughan
Oct 1, 1974·Journal of Pharmaceutical Sciences·E R Garrett, J Tsau
Aug 1, 1968·Tetrahedron·R MechoulamY Gaoni
Dec 7, 2000·Chemistry and Physics of Lipids·R Mechoulam, L Hanus
Dec 31, 2002·Chemistry and Physics of Lipids·Raphael Mechoulam, Lumír Hanus
Mar 1, 2005·Forensic Science International : Synergy·Franz E DussyThomas A Briellmann
Jul 8, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sridhar ThummaMichael A Repka
Mar 25, 2010·Pharmacology, Biochemistry, and Behavior·Abir T El-AlfySamir Ross
Sep 29, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ariane WohlfarthVolker Auwärter
Sep 13, 2016·Chemical Research in Toxicology·Judy L Bolton, Tareisha Dunlap
Jun 2, 2017·Drug Testing and Analysis·Lambert K Sørensen, Jørgen B Hasselstrøm
Apr 1, 2016·Cannabis and Cannabinoid Research·John MerrickStan L Banks
Feb 7, 2018·Journal of Pharmaceutical Analysis·Xiaoming LiangXiaohui Chen

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