Kinetics of circulating fetuin-A may predict mortality independently from adiponectin, high molecular weight adiponectin and prognostic factors in critically ill patients with sepsis: A prospective study

Journal of Critical Care
Irene KarampelaMaria Dalamaga

Abstract

Fetuin-A and adiponectin, major hepatokine and adipokine respectively, have been implicated in systematic inflammation. Our aim was to jointly investigate whether kinetics of circulating fetuin-A, adiponectin and its isoform HMWA predict 28-day mortality in sepsis. In a prospective study, serum fetuin-A, adiponectin and HMWA were determined in 102 ICU patients fulfilling the diagnostic criteria of SEPSIS-3, at enrollment and one week after, and in 102 healthy controls matched on age and gender. Serum fetuin-A was significantly lower in septic patients than controls (p<0.001). Among septic patients, those with septic shock and nonsurvivors presented lower fetuin-A, but higher adiponectin and HMWA compared to patients with sepsis and survivors respectively, both at baseline and day 7 (p<0.001). Fetuin-A exhibited negative correlations with APACHE II, CRP, procalcitonin, adiponectin and IL-6 but a positive one with albumin. Reduced fetuin-A as well as lower serum kinetics of fetuin-A (HR: 0.55, 95% C.I. 0.34-0.91, p=0.02), adiponectin but not HMWA were independently associated with 28-day mortality adjusting for age, gender, BMI, APACHE II, septic shock and laboratory biomarkers. Circulating fetuin-A kinetics may be a prognostic b...Continue Reading

Citations

Oct 12, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ichiro WakabayashiJoji Kotani
Nov 6, 2018·The Journal of Clinical Endocrinology and Metabolism·Maria Giovanna ScaraleClaudia Menzaghi
Aug 8, 2019·BMC Infectious Diseases·Halil DeğirmencioğluCüneyt Tayman
Jun 9, 2020·Veterinary Clinical Pathology·Carlos TorrenteAsta Tvarijonaviciute
Jun 27, 2020·Critical Care Medicine·Nikhil JaganMark A Malesker
Dec 22, 2017·Diabetes·Claudia Menzaghi, Vincenzo Trischitta
Jun 22, 2020·Current Obesity Reports·Irene KarampelaMaria Dalamaga
May 21, 2020·Critical Care : the Official Journal of the Critical Care Forum·Michael BauerDaniel Adam
Jul 7, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Hülya UlusoyÜmitcan Ok
Nov 20, 2021·Frontiers in Cardiovascular Medicine·Shingo MitsudaAkira Ushiyama

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