PMID: 11929240Apr 4, 2002Paper

Kinetics of disassembly of a DNA-bound porphyrin supramolecular array

Journal of the American Chemical Society
Robert F PasternackKelly Shannon Engstrom

Abstract

trans-Bis(N-methylpyridinium-4-yl)diphenylporphine forms extended, organized assemblies on DNA templates under appropriate conditions of concentration, ionic strength, and temperature. Addition of beta-cyclodextrin to these arrays leads to their disassembly as evidenced by changes in extinction, circular dichroism, and resonance light scattering spectra. The structure or flexibility of the polymer template has an effect on the rate of disassembly; the reaction is faster on a poly(dG-dC)(2) surface than on ct DNA. The kinetic profiles for the disassembly process can be fit with great precision with a two-kinetic parameter equation in which the rate constant is itself a function of time. The reaction rate, studied in the presence of excess beta-CD, shows a dependence on the mode of detection. A model is presented to account for these observations in which the arrays become increasingly reactive with time due to beta-CD attack at the interior of the porphyrin assemblies as well as the ends.

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Citations

Sep 15, 2012·Inorganic Chemistry·Ilaria OcchiutoRobert F Pasternack
May 12, 2005·Chemical Communications : Chem Comm·Donato MontiRoberto Paolesse
Jul 12, 2007·Chemical Communications : Chem Comm·Yusuke IshiiYuji Kubo
Dec 11, 2007·Nucleosides, Nucleotides & Nucleic Acids·Imenne BouamaiedEugen Stulz
Apr 28, 2004·Bioorganic & Medicinal Chemistry Letters·Song WuXiaoping Cao
Apr 12, 2012·Angewandte Chemie·Vladimir L MalinovskiiRobert Häner
Mar 7, 2007·Organic & Biomolecular Chemistry·Petr StepánekPavel Drasar
Aug 30, 2008·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Igor SazanovichVladimir Chirvony
Aug 16, 2008·Journal of Separation Science·Xin LuShulin Zhao
Nov 22, 2019·Chemical Communications : Chem Comm·Maxime VoneschJean Weiss
Nov 19, 2020·International Journal of Molecular Sciences·Marco SavioliDonato Monti
Sep 17, 2009·Journal of the American Chemical Society·Jeroen C GielenPeter C M Christianen
Nov 17, 2007·Journal of the American Chemical Society·Leslie-Anne FendtEugen Stulz
Aug 29, 2019·ACS Omega·Mariachiara TrapaniRobert F Pasternack
May 10, 2007·Journal of the American Chemical Society·Donato MontiRoberto Paolesse
Jun 8, 2006·Journal of the American Chemical Society·Luigi Monsù ScolaroFranco Felici

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