Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models

Journal of Pharmacokinetics and Pharmacodynamics
Meindert Danhof

Abstract

Gerhard Levy started his investigations on the "Kinetics of Drug Action in Disease States" in the fall of 1980. The objective of his research was to study inter-individual variation in pharmacodynamics. To this end, theoretical concepts and experimental approaches were introduced, which enabled assessment of the changes in pharmacodynamics per se, while excluding or accounting for the cofounding effects of concomitant changes in pharmacokinetics. These concepts were applied in several studies. The results, which were published in 45 papers in the years 1984-1994, showed considerable variation in pharmacodynamics. These initial studies on kinetics of drug action in disease states triggered further experimental research on the relations between pharmacokinetics and pharmacodynamics. Together with the concepts in Levy's earlier publications "Kinetics of Pharmacologic Effects" (Clin Pharmacol Ther 7(3): 362-372, 1966) and "Kinetics of pharmacologic effects in man: the anticoagulant action of warfarin" (Clin Pharmacol Ther 10(1): 22-35, 1969), they form a significant impulse to the development of physiology-based pharmacodynamic (PBPD) modeling as novel discipline in the pharmaceutical sciences. This paper reviews Levy's research on...Continue Reading

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Citations

Sep 26, 2015·Journal of Pharmacokinetics and Pharmacodynamics·Ho-Leung Fung, William J Jusko
May 2, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Meindert Danhof
Oct 19, 2016·Journal of Pharmaceutical Sciences·Rodrigo Cristofoletti, Jennifer B Dressman
Dec 22, 2019·Clinical Pharmacology and Therapeutics·Sebastiaan C GouloozeCatherijne A J Knibbe
Feb 6, 2017·Clinical and Translational Science·M L RizkK E Dooley
Sep 21, 2021·Journal of Biochemical and Molecular Toxicology·Natália H FerreiraDenise C Tavares

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