Kinetics of filament bundling with attractive interactions

Biophysical Journal
Xueping Yu, A E Carlsson

Abstract

We study the kinetics of filament bundling by variable time-step Brownian-dynamics simulations employing a simplified attractive potential based on earlier atomic-level calculations for actin filaments. Our results show that collisions often cluster in time, due to memory in the random walk. The clustering increases the bundling opportunities. Small-angle collisions and collisions with short center-to-center distance are more likely to lead to bundling. Increasing the monomer-monomer attraction decreases the bundling time to a diffusional limit, which is determined by the capture cross-section and diffusion coefficients. The simulations clearly show that the bundling process consists of two sequential phases: rotation, by which two filaments align parallel to each other; and sliding, by which they maximize their contact length. Whether two filaments bundle or not is determined by the competition between rotation to a parallel state and escape. Increasing the rotational diffusion coefficient and attraction enhances rotation; decreasing attraction and increasing the translational diffusion coefficients enhance escape. Because of several competing effects, the filament length only affects the bundling time weakly.

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S H Northrup, H P Erickson
Apr 12, 1996·The Journal of Biological Chemistry·J X Tang, P A Janmey
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·A A Kornyshev, S Leikin
Feb 19, 2000·Current Opinion in Structural Biology·J C Rochet, P T Lansbury
Feb 13, 2001·Biophysical Journal·M J Stevens
Jul 20, 2001·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·A DiehlY Levin
Aug 11, 2001·Physical Review Letters·A G Moreira, R R Netz
Apr 24, 2002·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·B I Shklovskii
Nov 22, 2002·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·A W C Lau, P Pincus
Apr 30, 2003·Biopolymers·Gerald S Manning

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Citations

Dec 10, 2009·European Biophysics Journal : EBJ·Carmel BonetAngel Mozo-Villarías
Oct 20, 2010·Journal of Mathematical Biology·K-C LeeJ M Schwarz
May 31, 2012·Nature Communications·Tobias T FalzoneMargaret L Gardel
Aug 25, 2015·The Journal of Chemical Physics·Kyle T Brady, Joseph E Reiner
Mar 28, 2006·Biophysical Journal·Le YangA E Carlsson
Oct 21, 2009·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Hossein FazliRamin Golestanian
Oct 15, 2008·Physical Review Letters·Pavel KraikivskiIgor L Novak
Oct 23, 2008·The Journal of Biological Chemistry·Thomas D Pollard, Julien Berro
Nov 13, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Hossein Fazli, Ramin Golestanian
May 21, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·P Terech

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