Kinetics of HIV-Specific CTL Responses Plays a Minimal Role in Determining HIV Escape Dynamics

Frontiers in Immunology
Yiding Yang, Vitaly V Ganusov

Abstract

Cytotoxic T lymphocytes (CTLs) have been suggested to play an important role in controlling human immunodeficiency virus (HIV-1 or simply HIV) infection. HIV, due to its high mutation rate, can evade recognition of T cell responses by generating escape variants that cannot be recognized by HIV-specific CTLs. Although HIV escape from CTL responses has been well documented, factors contributing to the timing and the rate of viral escape from T cells have not been fully elucidated. Fitness costs associated with escape and magnitude of the epitope-specific T cell response are generally considered to be the key in determining timing of HIV escape. Several previous analyses generally ignored the kinetics of T cell responses in predicting viral escape by either considering constant or maximal T cell response; several studies also considered escape from different T cell responses to be independent. Here, we focus our analysis on data from two patients from a recent study with relatively frequent measurements of both virus sequences and HIV-specific T cell response to determine impact of CTL kinetics on viral escape. In contrast with our expectation, we found that including temporal dynamics of epitope-specific T cell response did not i...Continue Reading

References

Jan 1, 1997·Annual Review of Immunology·A J McMichael, R E Phillips
Mar 22, 2002·Nature Reviews. Immunology·Alan S Perelson
Oct 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rob J De BoerAlan S Perelson
Aug 3, 2004·Nature Reviews. Immunology·Philip J R Goulder, David I Watkins
Apr 11, 2006·PLoS Computational Biology·Vitaly V Ganusov, Rob J De Boer
Feb 15, 2008·Journal of Virology·Janka PetravicMiles P Davenport
Jul 19, 2008·PLoS Computational Biology·Christian L Althaus, Rob J De Boer
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emma L TurnbullPersephone Borrow
Jun 3, 2009·The Journal of Experimental Medicine·Nilu GoonetillekeAndrew J McMichael
Dec 17, 2009·Nature Reviews. Immunology·Andrew J McMichaelBarton F Haynes
Mar 2, 2011·Nature Medicine·Morgane RollandJames I Mullins
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lina JosefssonSarah E Palmer
Oct 13, 2011·Nature Medicine·Bruce D WalkerStanley Plotkin
Dec 12, 2012·The Journal of Clinical Investigation·Michael K P LiuNilu Goonetilleke
Aug 14, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hanneke W M van DeutekomRob J de Boer
Sep 13, 2013·Frontiers in Immunology·Taylor A KessingerRichard A Neher
Jan 1, 2013·Journal of Statistical Mechanics : Theory and Experiment·Vitaly V GanusovAlan S Perelson
May 17, 2014·PLoS Computational Biology·Vitaly V Ganusov, Jeremy Auerbach
Jan 30, 2015·Frontiers in Immunology·Victor Garcia, Roland Robert Regoes
Apr 1, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexey P MartyushevMiles P Davenport
Oct 28, 2015·PLoS Computational Biology·Sivan Leviyang, Vitaly V Ganusov
May 24, 2016·Nature Communications·John P BartonArup K Chakraborty

❮ Previous
Next ❯

Citations

Aug 30, 2019·Current Opinion in Systems Biology·Jessica M Conway, Ruy M Ribeiro
May 15, 2021·The Journal of Experimental Medicine·Chase D McCannR Brad Jones

❮ Previous
Next ❯

Software Mentioned

Mathematica

Related Concepts