Kinetics of interleukin-6 production after experimental infection of mice with Schistosoma mansoni

Immunology
R M KhalilP Dörmer

Abstract

It has been reported that interleukin-6 (IL-6) is expressed in cells of acute inflammatory granulomas experimentally induced in mice by eggs of Schistosoma mansoni. Moreover, in vitro IL-6 was shown to enhance the cytotoxic activity of human platelets against larvae of S. mansoni. To elucidate further a proposed biological significance of this cytokine during the course of schistosomiasis, we studied the kinetics of IL-6 production and concomitantly performed a histopathological analysis of the livers in BALB/c mice subcutaneously infected with S. mansoni cercariae. Over a period of 24 weeks postinfection (p.i.) we monitored serum IL-6 levels, IL-6 production in vitro by pokeweed mitogen (PWM)-stimulated spleen cells as well as IL-6 mRNA expression in livers, spleens and kidneys. We found significantly elevated IL-6 levels in PWM-stimulated spleen cell-conditioned media (SCM) at weeks 6 to 20 p.i., peaking at week 10 p.i. In contrast, serum IL-6 concentrations started to rise not before week 8 but remained significantly elevated above normal control values until week 24 p.i. The time pattern of enhanced IL-6 mRNA expression detected in spleens and livers, but not in kidneys, as well as the rises of IL-6 in SCM and with a delay ...Continue Reading

References

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Citations

Sep 25, 2002·Transplantation Proceedings·A C Papassavas, C Stavropoulos-Giokas
May 20, 2015·Cytokine·Justin S AntonyThirumalaisamy P Velavan
Apr 24, 2014·Mediators of Inflammation·Jamille Souza FernandesLuciana Santos Cardoso
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L HültnerE Schmitt

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