Kinetics of intravenously dosed cortisol in four men. Consequences for calculation of the plasma cortisol production rate

The Journal of Steroid Biochemistry and Molecular Biology
G P KraanR de Bruin

Abstract

The kinetics of cortisol in the serum of 4 healthy men were studied following single i.v. doses of 2 and 0.8 mg of cortisol. The disappearance of cortisol was determined by blood sampling frequently over 2.5 h and analysing the apparently biexponential cortisol decay. The main results, shown as the mean (+/-SD), were: (a) the average distribution volume of cortisol at steady state (Vd,ss), which was 7.1 l/m2 body surface area. The extrapolated distribution volume (Vd,ext) was 8.4 l/m2, being 18% higher than the corresponding Vd,ss. (b) It was confirmed that plasma cortisol disappears biexponentially. Since the rapid phase remains unnoticed if cortisol is measured at an interval of 10 or more minutes, the obscured rapid-phase parameters can be found only if the known ratio of the two rate constants is used. (c) The fraction of cortisol, which during this fast phase irreversibly disappeared according to the two-compartment open model, was 5 to 8% larger than that found using the monocompartment model. (d) The half-life of the slow or beta phase was equal for the 2 and 0.8 mg experiments, namely t1/2(beta) = 66 +/- 18 min. The kinetics of cortisol in the same 4 men were also measured after an i.v. dose of radioactive cortisol (82 ...Continue Reading

References

Feb 1, 1975·The Journal of Clinical Endocrinology and Metabolism·W J JuskoT Aceto
May 1, 1991·Journal of Clinical Pharmacology·H DerendorfM Krieg
Feb 1, 1974·The Journal of Clinical Endocrinology and Metabolism·B ZumoffL Hellman
Apr 1, 1982·Journal of Pharmacokinetics and Biopharmaceutics·R D Toothaker, P G Welling
May 1, 1956·The Journal of Clinical Investigation·R E PETERSON, J B WYNGAARDEN
Jan 1, 1961·The Journal of Clinical Investigation·J F TAITK R LAUMAS

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Citations

Feb 1, 2007·Pituitary·Christoph J Auernhammer, George Vlotides
Aug 28, 2001·Clinical Biochemistry·M VogeserK Jacob
Sep 18, 2004·Archives of Gerontology and Geriatrics·R N BartonJ G Rose
Jun 19, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daniel M KeenanJohannes D Veldhuis
Aug 21, 2013·BioMed Research International·Darine Trabelsi, Ridha Mhamdi
Jul 15, 2011·The Journal of Clinical Endocrinology and Metabolism·Johannes D VeldhuisDaniel M Keenan
Feb 18, 2012·The Journal of Clinical Endocrinology and Metabolism·Richard I DorinFrank K Urban
Jan 7, 2005·Clinical Pharmacokinetics·David CzockUlla Häussler
Mar 28, 2008·Expert Opinion on Investigational Drugs·Kristian Løvås, Eystein S Husebye
Oct 16, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter Y LiuJohannes D Veldhuis
Apr 23, 2009·The New Phytologist·Marlis ReichAndrea Polle
Oct 29, 2009·American Journal of Physiology. Endocrinology and Metabolism·Daniel J VisAge K Smilde
Nov 5, 2014·Critical Care Medicine·Richard I DorinFrank K Urban
Dec 19, 2015·Physiological Research·K SimunkovaL Starka
Dec 22, 2017·Journal of the Endocrine Society·Richard I DorinFrank K Urban

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