PMID: 6969316Sep 30, 1980Paper

Kinetics of ionic transport across frog skin: two concentration-dependent processes

The Journal of Membrane Biology
J Ehrenfeld, F Garcia-Romeu

Abstract

Sodium and chloride influxes across the nonshort-circuited isolated skin of Rana esculenta were measured at widely varying external ionic concentrations. The curve describing sodium transport has two Michaelis-Menten components linked at an inflection point occurring at an external sodium concentration of about 7 meq. Chloride transport can also be represented by two saturating components. A possible explanation of these kinetics is discussed. At sodium concentrations lower than 4 meq it is possible to define a component of the sodium transport mechanism as having a high affinity for sodium and which is independent of the nature of the external anion. A high affinity for chloride of the chloride transport system functioning at low external concentrations is also found but is significantly different from that of sodium. These systems show the physiological characteristics of the countertransports (Na est(+)/H int(+); Cl ext(-)/HCO 3int(-)) functioning at low external concentrations. At external concentrations higher than 4 meq a low affinity transporting system in which chloride and sodium are linked superimpose on the high affinity compoents. The physiological significance of these results is discussed.

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Citations

Oct 1, 1988·Pflügers Archiv : European journal of physiology·F Lacaz-Vieira, J Procopio
May 1, 1989·Pflügers Archiv : European journal of physiology·J EhrenfeldB J Harvey
Nov 8, 2002·Biochimica Et Biophysica Acta·S SchmiederJ Ehrenfeld
Mar 20, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·J Ehrenfeld
Oct 1, 1986·Acta Physiologica Scandinavica·A F Harck, E H Larsen
Jan 20, 2004·Biochimica Et Biophysica Acta·Lars Jørn JensenErik Hviid Larsen
Oct 1, 1987·Journal of Pharmaceutical Sciences·R R Burnette, B Ongpipattanakul
Aug 1, 1981·Biological Reviews of the Cambridge Philosophical Society·T Magnuson, C J Epstein
Aug 1, 1981·Biological Reviews of the Cambridge Philosophical Society·M H Johnson

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