PMID: 8611610Jan 12, 1996Paper

Kinetics of membrane micellization by the hydrophobic polyelectrolyte poly(2-ethylacrylic acid)

Biochimica Et Biophysica Acta
J L ThomasD A Tirrell

Abstract

Rates of pH-dependent micellization of multilamellar vesicles by the hydrophobic polyelectrolyte poly(2-ethylacrylic acid) (PEAA) have been measured turbidometrically. This polymer shows a strong ph-dependence in its affinity for phospholipid membranes, binding in increasing amounts as pH is lowered and ultimately solubilizing membranes to form mixed micelles (Tirrell, Takigawa and Seki (1985) Ann. N.Y. Acad. Sci. 446, 237). The rate of solubilization of dipalmitoylphosphatidylcholine (DPPC) vesicle suspensions by PEAA increases approximately linearly with reductions in pH below a threshold at pH 6.55. Interestingly, negatively-charged dipalmitoylphosphatidylglycerol membranes showed qualitatively similar behavior in the presence of PEAA, and incorporation of 10% or 20% dipalmitoylphosphatidic acid in DPPC membranes did not affect solubilization rates, demonstrating that membrane charge is not an important factor in determining micellization kinetics. Micellization of DPPC and dimyristoylphosphatidylcholine membranes occurs most rapidly at their respective gel-liquid crystalline transition temperatures (Tm); the rate enhancement is correlated with a peak in the temperature-dependent binding of a fluorescently-modified PEAA in s...Continue Reading

References

Nov 2, 1978·Biochimica Et Biophysica Acta·J F Nagle, H L Scott
Jan 1, 1985·FEBS Letters·R M StraubingerD Papahadjopoulos
Jan 1, 1985·Annals of the New York Academy of Sciences·D A TirrellK Seki

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Citations

Apr 7, 2004·Advanced Drug Delivery Reviews·Marie-Andrée Yessine, Jean-Christophe Leroux
Jul 3, 1999·Chemistry and Physics of Lipids·J A Boomer, D H Thompson
Sep 6, 2003·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Chirasak KusonwiriyawongElke Walter
Jun 6, 2000·Advanced Drug Delivery Reviews·O V GerasimovD H Thompson
Jan 22, 2015·Biophysical Journal·Stefan ScheidelaarJ Antoinette Killian
Nov 5, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Masafumi TanakaTakahiro Mukai
Jun 28, 2011·Biochimica Et Biophysica Acta·Anna K BerkovichNickolay S Melik-Nubarov
May 1, 2009·Expert Review of Clinical Pharmacology·Mustafa AkbulutRobert K Prud'homme
May 29, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·J L Thomas, D A Tirrell1
Nov 18, 2000·Progress in Lipid Research·D C DrummondJ Leroux
Jun 23, 2015·Biomacromolecules·Francesca ErcoleThomas P Davis

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