PMID: 8938223Jan 1, 1996Paper

Kinetics of [methyl-11C]thymidine in patients with squamous cell carcinoma of the head and neck

Acta Oncologica
M van EijkerenK Strijckmans

Abstract

Thymidine labelled with a position emitter and imaging by positron emission tomography has been suggested to measure tumour proliferation in vivo non-invasively. The present study presents a compartmental model which describes the behavior of [methyl-11C]thymidine in tumour tissue and allows quantification of the data using a proliferation parameter (PP). In nine patients with squamous cell carcinoma of the head and neck, 11C-activity over the tumour and the adjacent blood vessels was measured. The median PP without correction for blood pool activity was found to be 8.61 10(-4) min(-1). With correction this parameter changed from -14% to +40%. We found no correlation between either sex or tumour differentiation and PP. The described model can be used to quantitate [methyl-11C]thymidine uptake in human tumours. Indivdual correction for tumour blood volume is mandatory.

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Citations

Aug 28, 1999·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·C J SteelP M Price
Nov 11, 1998·Nature Medicine·A F ShieldsT J Mangner
Sep 26, 2007·Expert Review of Molecular Diagnostics·Evan Y Yu, David A Mankoff
Jan 22, 2004·Seminars in Nuclear Medicine·Abass AlaviHongming Zhuang
Oct 19, 2004·Radiologic Clinics of North America·Abass AlaviHongming Zhuang
Feb 8, 2005·Radiologic Clinics of North America·David A MankoffKenneth A Krohn
Jul 1, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·James R Bading, Anthony F Shields
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·D A MankoffA F Shields

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