Kinetics of microglial activation and degeneration of dopamine-containing neurons in a rat model of Parkinson disease induced by 6-hydroxydopamine

Journal of Neuropathology and Experimental Neurology
Vincent HenryPhilippe Damier

Abstract

In both Parkinson disease and in animal models of Parkinson disease, there is a microglial reaction in addition to the loss of dopaminergic neurons in the ventral midbrain. To determine the pathological role of this microglial reaction, we analyzed the kinetics of microglial activation and dopaminergic cell death induced in rats with the neurotoxin 6-hydroxydopamine. As early as Day 1 after the injection, there was a decline in the motor performance of the 6-hydroxydopamine-lesioned rats that correlated with a reduction of dopaminergic innervation of the contralateral striatum. Loss of dopaminergic neurons in the ventral midbrain developed a few days later and seemed to follow a specific temporospatial pattern. Degenerating neurons and activated microglia were seen only in areas in which dopaminergic cells were no longer observed, suggesting that the loss of the dopaminergic phenotype preceded the degenerative process. In sham-lesioned rats, there was a transient activation of microglia in the vicinity of the needle tract without any cell degeneration. This chronology of events supports the hypothesis that microglial activation is a secondary rather than primary phenomenon in dopaminergic cell degeneration induced by 6-hydroxyd...Continue Reading

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May 11, 2011·Journal of Neuroinflammation·Lalida RojanathammaneeColin K Combs
Feb 13, 2016·Frontiers in Molecular Neuroscience·Stefan Jean-Pierre HaasBjörn Spittau
Jul 9, 2010·Progress in Neurobiology·Elisabetta Polazzi, Barbara Monti
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Apr 9, 2020·International Journal of Molecular Sciences·Thomas NuryAnne Vejux
Jan 30, 2021·Frontiers in Pharmacology·Maurício Dos Santos PereiraElaine Del Bel
Jun 3, 2021·International Journal of Molecular Sciences·Marcello SerraFrancesco Napolitano

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