Kinetics of peptide secondary structure conversion during amyloid β-protein fibrillogenesis

Journal of Theoretical Biology
Timothy SteckmannPrem P Chapagain

Abstract

Amyloid fibrils are a common component in many debilitating human neurological diseases such as Alzheimer's (AD), Parkinson's, and Creutzfeldt-Jakob, and in animal diseases such as BSE. The role of fibrillar Αβ proteins in AD has stimulated interest in the kinetics of Αβ fibril formation. Kinetic models that include reaction pathways and rate parameters for the various stages of the process can be helpful towards understanding the dynamics on a molecular level. Based upon experimental data, we have developed a mathematical model for the reaction pathways and determined rate parameters for peptide secondary structural conversion and aggregation during the entire fibrillogenesis process from random coil to mature fibrils, including the molecular species that accelerate the conversions. The model and the rate parameters include different molecular structural stages in the nucleation and polymerization processes and the numerical solutions yield graphs of concentrations of different molecular species versus time that are in close agreement with experimental results. The model also allows for the calculation of the time-dependent increase in aggregate size. The calculated results agree well with experimental results, and allow diffe...Continue Reading

References

Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·A LomakinD B Teplow
Aug 1, 1998·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·D B Teplow
Aug 28, 1999·The Journal of Biological Chemistry·D M WalshD B Teplow
Mar 22, 2000·Biochemistry·T L BenzingerS C Meredith
Aug 1, 2002·The Journal of Biological Chemistry·Youcef Fezoui, David B Teplow
May 14, 2003·The Journal of Cell Biology·Jeffery W Kelly, William E Balch
Jul 4, 2003·The Journal of Biological Chemistry·Gal BitanDavid B Teplow
Aug 28, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Massimo Stefani, Christopher M Dobson
Nov 16, 2005·Accounts of Chemical Research·Normand Mousseau, Philippe Derreumaux
Feb 28, 2006·Protein Science : a Publication of the Protein Society·Andrij BaumketnerJoan-Emma Shea
Jun 27, 2006·Journal of Molecular Biology·Riccardo Pellarin, Amedeo Caflisch
Apr 21, 2007·Epidemiology and Infection·P P ChapagainY T Grohn
Jun 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Wei-Feng XueSheena E Radford
Dec 31, 2008·Physical Review Letters·Stefan AuerAmos Maritan
Jan 29, 2009·The Journal of Chemical Physics·Jianing Zhang, M Muthukumar
Nov 13, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Chiu Fan Lee
Jun 10, 2010·The Journal of Chemical Physics·Dimo Kashchiev, Stefan Auer
Apr 14, 2011·The Journal of Physical Chemistry. B·Camilo Velez-Vega, Fernando A Escobedo

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Citations

Jun 24, 2015·Biophysical Chemistry·Maria Giovanna Di CarloMaurizio Leone
Nov 20, 2013·Molecular Medicine Reports·Tsutomu ArakawaYoshiko Kita
May 7, 2020·Scientific Reports·Shayon BhattacharyaDamien Thompson
Apr 10, 2017·The Journal of Chemical Physics·Timothy SteckmannBernard S Gerstman

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