Kinetics of pharmacologic response. I. Proposed relationships between response and drug concentration in the intact animal and man
No abstract listed.
Theoretical relationship between dose, elimination rate, and duration of pharmacologic effect of drugs
A QUANTITATIVE INVESTIGATION OF THE RELATIONSHIP BETWEEN RATE OF ACCESS OF A DRUG TO RECEPTOR AND THE RATE OF ONSET OR OFFSET OF ACTION
RELATIONSHIP BETWEEN RATE OF ELIMINATION OF TUBOCURARINE AND RATE OF DECLINE OF ITS PHARMACOLOGICAL ACTIVITY
Corticosteroid pharmacodynamics: models for a broad array of receptor-mediated pharmacologic effects
Coupling toxicokinetics and pharmacodynamics for predicting survival of abalone (Haliotis diversicolor supertexta) exposed to waterborne zinc
Relationship between plasma delta-9-tetrahydrocannabinol concentration and pharmacologic effects in man
An artificial neural network-based controller for the control of induced paralysis using vecuronium bromide
A new modeling approach to the effect of antimicrobial agents on heterogeneous microbial populations
Structural identifiability and indistinguishability of certain two-compartment models incorporating nonlinear efflux from the peripheral compartment
Plasma prednisolone concentrations: comparison of radioimmunoassay and competitive protein binding assay
A pharmacokinetic/pharmacodynamic/receptor binding model to predict the onset and duration of pharmacological activity of the benzodiazepines
Allylamine cardiovascular toxicity: V. Tissue distribution and toxicokinetics after oral administration
Evaluation of the free ion activity model of metal-organism interaction: extension of the conceptual model
The dose-response and time-effect relationships of intrathecal bupivacaine in rats. The influence of epinephrine and pH
Pharmacokinetic-pharmacodynamic modelling of the anticonvulsant effect of oxazepam in individual rats
Pharmacokinetic and pharmacodynamic studies of the histamine H1-receptor antagonist ebastine in dogs
Reconstruction of in vivo time-evolving neuroendocrine dose-response properties unveils admixed deterministic and stochastic elements
A biomathematical model of the restoring effects of caffeine on cognitive performance during sleep deprivation
Cortical cultures coupled to micro-electrode arrays: a novel approach to perform in vitro excitotoxicity testing
Novel GM1 ganglioside-like peptide mimics prevent the association of cholera toxin to human intestinal epithelial cells in vitro
Comparison in young and elderly patients of pharmacodynamics and disposition of labetalol in systemic hypertension
The threshold effect: consequence of change in the frequency of food intake in the presence of a functional threshold
A Gompertz age-specific mortality rate model of aging, hormesis, and toxicity: dose-response studies
The use of mode of action information in risk assessment: quantitative key events/dose-response framework for modeling the dose-response for key events
Viral pharmacodynamic model for (-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine (emtricitabine) in chronically infected woodchucks
A phase I and pharmacokinetic study of pegylated camptothecin as a 1-hour infusion every 3 weeks in patients with advanced solid malignancies
The organism as bioreactor. Interpretation of the reduction law of metabolism in terms of heterogeneous catalysis and fractal structure
Dose-dependent decline of pharmacologic effects of drugs with linear pharmacokinetic characteristics
The relationship between receptor-effector unit heterogeneity and the shape of the concentration-effect profile: pharmacodynamic implications
Pharmacokinetic-pharmacodynamic modeling: time-dependent protein binding--an alternative interpretation of clockwise and counterclockwise hysteresis
The threshold effect: consequences of change in the frequency of food intake in the presence of a functional threshold
Microbial pharmacodynamics of piperacillin in neutropenic mice of systematic infection due to Pseudomonas aeruginosa
Pharmacokinetic interpretation of the enterohepatic recirculation and first-pass elimination of morphine in the rat
Awakening propofol concentration with and without blood-effect site equilibration after short-term and long-term administration of propofol and fentanyl anesthesia
Role of potassium channels in isoflurane- and sevoflurane-induced attenuation of hypoxic pulmonary vasoconstriction in isolated perfused rabbit lungs
Response of cyclic AMP by DMSO differentiated HL-60 cells exposed to electric interferential current after prestimulation
Pharmacokinetic-pharmacodynamic modelling and simulation using the electrical circuit simulation program SPICE2
A general model for time-dissociated pharmacokinetic-pharmacodynamic relationship exemplified by paclitaxel myelosuppression
Introduction of quantitative methods in pharmacology and clinical pharmacology: a historical overview
A concept for pharmacokinetic-pharmacodynamic dosage adjustment in renal impairment: the case of aminoglycosides
Logistic Models for Simulating the Growth of Plants by Defining the Maximum Plant Size as the Limit of Information Flow.
A novel use of hill function and utility of 99mTc-MIBI scintigraphy to detect earlier lower extremity microvascular perfusion in patients with type 2 diabetes
Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia.
The effect of quinidine and its metabolites on the electrocardiogram and systolic time intervals: concentration--effect relationships
Influence of intrinsic sympathomimetic activity of beta-adrenoceptor blockers on the heart rate and blood pressure responses to graded exercise
A simulation of neuromuscular function and heart rate during induction, maintenance, and reversal of neuromuscular blockade
Relationship between plasma concentration and effect of midazolam after oral and intravenous administration
Sublingual buprenorphine used postoperatively: clinical observations and preliminary pharmacokinetic analysis
Relationship between gallamine plasma concentration and neuromuscular paralysis in surgical patients
Phase I trial, including pharmacokinetic and pharmacodynamic correlations, of combination paclitaxel and carboplatin in patients with metastatic non-small-cell lung cancer
On Dr Dick Climie and Dr Jack Thomas, and the genesis of chemical-clinical pharmacology in Australian anaesthesia research
Application of Pharmacokinetic-Pharmacodynamic Modeling in Drug Delivery: Development and Challenges
Alcuronium pharmacodynamics in dogs: effect-concentration relationships in the diaphragmatic and limb muscles
Pharmacokinetics of the gamma-aminobutyric acid agonist THIP (Gaboxadol) following intramuscular administration to man, with observations in dog
Pharmacokinetics of theophylline and 3-methylxanthine in guinea pigs. II. Multiple dose administration
Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer's Disease
Pharmacokinetics and biopharmaceutics of some adrenergic beta-receptor antagonists with special emphasis on alprenolol and metoprolol
Pharmacokinetic and pharmacodynamic modeling of cibenzoline plasma concentrations and antiarrhythmic effect
Sensitivity of action potential triggering is normally distributed as a function of mean fractional receptor activation
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
STING Receptor Agonists
Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.
Chronic Fatigue Syndrome
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Spatio-Temporal Regulation of DNA Repair
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Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.
Hereditary Sensory Autonomic Neuropathy
Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.
Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.
Neural Activity: Imaging
Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.
Applications of Molecular Barcoding
The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.