PMID: 37940Jun 1, 1979

Kinetics of phenazepam-14C excretion from the body of white rats in the single and prolonged administration of the preparation

Biulleten' eksperimental'noĭ biologii i meditsiny
V G Zin'kovskiĭS A Andronati

Abstract

During 5 days after intraperitoneal injection of 14C-phenazepam into albino rats, about 77% of the total radioactivity was excreted with urine and feces in both intact animals and in those premedicated with phenazepam for 15 days. The excretory processes are described by the first order equations. The rates of phenazepam total excretion are identical in single and repeated injections. At the same time, phenazepam injected into the animals at a single dose is predominantly excreted with urine, while in multiple administration it is excreted with feces. Excretion of phenazepam with urine acquires the biexponential features, provided it is injected in multiple doses.

References

Feb 1, 1967·British Journal of Pharmacology and Chemotherapy·B K Martin

Citations

Aug 1, 1983·Biulleten' eksperimental'noĭ biologii i meditsiny·G M Molodavkin, S G Belousova
Sep 14, 2014·Forensic Science International : Synergy·Ritva KarinenÅse Marit Leere Øiestad
Jan 1, 1985·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·U Sprandel, N Zöllner
Jan 1, 1984·Applied Biochemistry and Biotechnology·T M Chang
Feb 1, 2018·Journal of Liposome Research·Gregory Gregoriadis

Related Concepts

Benzodiazepines
Carbon Radioisotopes
Feces
Anti-Anxiety Effect

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

© 2021 Meta ULC. All rights reserved