Dec 1, 1986

Kinetics of piretanide absorption from the gastrointestinal tract

Methods and Findings in Experimental and Clinical Pharmacology
D BrockmeierB H Meyer

Abstract

In a recent report, it was shown that the loop diuretic piretanide is rapidly absorbed after placement of a piretanide solution in the duodenum, while the rate of absorption is definitely slower when the drug is instilled into the ascending colon (5). When piretanide is instilled into the stomach, the absorption process does not differ significantly from that after placement in the duodenum, neither with respect to amount nor rate (5). However, it was not clear from this study whether piretanide is directly absorbed from the stomach or rapidly released into the duodenum. In a study with five volunteers piretanide was instilled into the stomach via a gastroscope. The volunteers took part in two trial phases in a randomized cross-over design: in one phase the administration of 6 mg piretanide was preceded by intravenous administration of 40 mg hyoscine-N-butylbromide (HNB) to immobilize the stomach while in the alternative phase this coadministration of HNB was omitted. Furthermore, the volunteers were lying on their left side to avoid the gastric fluid leaking out into the intestine by gravity. From the concentration-time-curves monitored it can be concluded that piretanide is absorbed directly from the stomach for almost all su...Continue Reading

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Mentioned in this Paper

Entire Gastrointestinal Tract
Duodenum
Salix - substance
Benign Neoplasm of Ascending Colon
Scopolamine
Gastric Emptying
HOE 118
Entire Intestinal Tract
Sulfonamides
Intestinal Wall Tissue

About this Paper

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