Kinetics of prostacyclin synthetase in umbilical artery microsomes from normal and pre-eclamptic pregnancies

British Journal of Clinical Pharmacology
I DowningP J Lewis

Abstract

1 Prostacyclin synthetase in umbilical artery microsomes obeys Michaelis-Menten kinetics. 2 The maximum velocity (Vmax) of prostacyclin synthetase prepared from normal umbilical arteries was significantly higher than the Vmax of prostacyclin synthetase in umbilical arteries taken from pre-eclamptic pregnancies. 3 The Michaelis-Menten constant (Km) of the two prostacyclin synthetase preparations was significantly different with the synthetase from pre-eclamptic arteries have a higher affinity for substrate. 4 The limiting factor for prostacyclin synthesis is Vmax at high substrate concentrations which appears to be the case in umbilical arteries. However, at low substrate concentration there would be no difference in prostacyclin synthesis by the two forms of prostacyclin synthetase.

References

Jun 1, 1978·The Journal of Clinical Endocrinology and Metabolism·R B EverettN F Gant
Sep 1, 1979·Prostaglandins·G RemuzziM B Donati
Sep 27, 1980·Lancet·F BussolinoG Camussi
Sep 20, 1980·Lancet·A BodzentaL Poller
Feb 21, 1981·Lancet·L O CarrerasA van Assche
Jun 28, 1980·British Medical Journal·P J LewisI Downing

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Citations

May 1, 1986·Canadian Anaesthetists' Society Journal·W D Writer
Mar 15, 1984·American Journal of Obstetrics and Gynecology·U M MäkiläO Ylikorkala
Jul 1, 1991·Placenta·C W Redman
Sep 1, 1992·British Journal of Obstetrics and Gynaecology·J Moodley, E Gouws
Jan 1, 1985·Medicinal Research Reviews·R C NickolsonH Vorbrüggen
Sep 1, 1993·Circulation·E A Meagher, G A FitzGerald
Feb 16, 1999·The American Journal of Clinical Nutrition·F V Velzing-AartsF A Muskiet

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