Kinetics of Prostate-Specific Antigen after Carbon Ion Radiotherapy for Prostate Cancer

Cancers
Narisa Dewi Maulany DarwisTatsuya Ohno

Abstract

This study aimed to first elucidate prostate-specific antigen (PSA) kinetics in prostate cancer patients treated with carbon ion radiotherapy (CIRT). From 2010 to 2015, 131 patients with prostate adenocarcinoma treated with CIRT (57.6 Gy relative biological effectiveness (RBE) in 16 fractions) alone were recruited. PSA was measured at 1, 2, 3, 6, 9, 12, 15, 18, 21, 24, 30, 36, 42, 48, 54, and 60 months post-CIRT. PSA bounce was defined as PSA increase over a cutoff followed by spontaneous decrease to or below the pre-bounce nadir. PSA failure was determined using the Phoenix criteria (nadir + 2.0 ng/mL). As a result, non-failure-associated temporary increase in PSA exhibited two distinct patterns, namely a classical bounce and a surge at one month. PSA bounce of ³0.2 ng/mL was observed in 55.7% of the patients. Bounce amplitude was <2.0 ng/mL in 97.6% of cases. Bounce occurred significantly earlier than PSA failure. Younger age was a significant predictor of bounce occurrence. Bounce positivity was a significant predictor of favorable 5-year PSA failure-free survival. Meanwhile, a PSA surge of ³0.2 ng/mL was observed in 67.9% of patients. Surge amplitude was significantly larger than bounce amplitude. Larger prostate volume was...Continue Reading

References

Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Anthony L ZietmanWilliam U Shipley
Sep 18, 2007·International Journal of Radiation Oncology, Biology, Physics·Juanita CrookGina Lockwood
May 3, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Darren M MitchellJohn P Logue
Jul 22, 2010·International Journal of Radiation Oncology, Biology, Physics·Murat CalogluEric A Klein
Apr 16, 2013·International Journal of Radiation Oncology, Biology, Physics·Niraj H MehtaJeffrey Demanes
Sep 26, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christopher R KingAlan Katz
Jul 25, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C ParkerUNKNOWN ESMO Guidelines Committee
Jul 13, 2016·British Journal of Cancer·Yoichiro YamamotoDavid Dingli
Nov 12, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Takuma NomiyaTadashi Kamada
Sep 9, 2018·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Lennart ÅströmLars Holmberg
May 16, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·James L MohlerDeborah A Freedman-Cass
Jul 6, 2019·International Journal of Radiation Oncology, Biology, Physics·Naomi Y JiangAmar U Kishan

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Citations

Aug 9, 2020·Cancers·Narisa Dewi Maulany DarwisTatsuya Ohno

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Software Mentioned

GraphPad
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