Kinetics of retinyl esters during postprandial lipemia in man: a compartmental model

Metabolism: Clinical and Experimental
N A LeJ A Cortner

Abstract

Orally ingested vitamin A (retinol) is incorporated into intestinal chylomicrons (CHYLO) in the form of retinyl esters (RE) along with newly absorbed dietary triglycerides (TG). As the intestinal lipoproteins undergo hydrolysis in the circulation, the majority of the RE remain with the secreted intestinal particles and have been used as a marker for intestinally derived lipoproteins during the early phase of the postprandial state. A multicompartmental model was developed for the kinetics of RE during postprandial lipemia in individuals with normal lipid levels (n = 16) and in patients with hyperlipidemia (n = 44). The assumptions used in the development of the model are presented in this report. Some of the key findings include (1) as much as 50% of the newly synthesized RE may be secreted by the intestine as very-low-density lipoprotein (VLDL)-sized particles of S(f) 20 to 400 following consumption of a test meal containing a moderate amount of fat (20 to 30 g); (2) in most individuals, approximately 50% of the RE secreted in S(f) greater than 400 are converted to smaller, less buoyant fractions, and 50% are irreversibly removed directly from the plasma; (3) as much as 5% to 20% of the ingested retinol may be secreted as smal...Continue Reading

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Citations

Dec 3, 1999·Journal of Internal Medicine·F Karpe
Dec 31, 2014·International Journal of Molecular Sciences·Ngoc-Anh Le
Aug 28, 2001·The American Journal of Clinical Nutrition·A J EdwardsR S Parker
Sep 10, 2010·International Journal of Cardiology·Genovefa D KolovouKatherine K Anagnostopoulou

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